Herbion® Laxana (Herbion® Laksana)

Archive
"Trade product
in Russia is not registered "
Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
Read on
Active substanceSennosides A and BSennosides A and B
Similar drugsTo uncover
  • Herbion® Laxana
    pills inwards 
    KRKA, dd, Novo mesto, AO    
  • Senadé®
    pills inwards 
    Cipla Ltd.     India
  • Senales
    pills inwards 
    Outline Pharma Pvt. Ltd.     India
  • Sennagood
    pills inwards 
    AVVA RUS, OJSC     Russia
  • Ex-Lax
    lozenges inwards 
    Novartis ExLax Inc.     Puerto Rico
    • Dosage form: & nbspfilm-coated tablets
    Composition:
    for 1 tablet, film-coated:
    CORE:
    Active ingredient:
    * Senna leaves extract dry, standardized, 33.5 mg
    is equivalent to 15 mg of the sum of hydroxyanthracenic glycosides in terms of sennoside B.
    Excipients: lactose monohydrate, microcrystalline cellulose, povidone, croscarmellose sodium, glycerol, silicon dioxide colloidal, anhydrous, magnesium stearate.
    SHELL: hypromellose, propylene glycol, talc, titanium dioxide, E171, ferric oxide brown oxide, E172.
    * Senna leaf extract dry standardized obtained by extracting the leaves of Senna plants - Cassia Acutifolia Del./Cassia Angustifolia Vahl., Family: Cesalpinia (f.Caesalpiniaceae). Extractant methanol 60%, the ratio of raw materials 25-45: 1.
    Description:
    Round tablets with a facet, covered with a film shell of dark brown color.
    Pharmacotherapeutic group:Laxative herbal remedy
    ATX: & nbsp

    A.06.A.B   Contact laxatives

    Pharmacodynamics:
    Pharmacodynamics. Gerbion® Laxan tablets are a purgative vegetable remedy that contains hydroxyanthracenic glycosides and sennosides that stimulate intestinal peristalsis.
    The laxative effect of the drug is due to the content of hydroxyanthracenic glycosides and sennosides. Laxative effects are 1,8-hydroxyanthracenic derivatives, formed as a result of metabolism in the large intestine. Sennosides and B-glycosides are not absorbed in the small intestine; in unchanged form enter the large intestine, where they are metabolized by bacteria of the intestinal flora to active metabolites - reynanthrones. Reynanthrons affect the peristalsis of the colon, enhancing propulsive contractions. At the same time, the time of contact of water and electrolytes with the intestinal mucosa is reduced, their absorption decreases and, as a result, the passage through the intestine of its contents is accelerated. Under the action of reynanthrones, the secretion of water and electrolytes in the lumen of the intestine is also enhanced by stimulation of active secretion of chlorides.Due to water retention in the lumen of the intestine, the contents of the intestine softens and its excretion is facilitated.
    Pharmacokinetics:
    After ingestion sennozidy practically not absorbed in the gastrointestinal tract (GIT). Glycosidic bonds are split in the large intestine and form sennidins, which under the action of bacterial reductases are converted into reynanthrons-active metabolites. The main quantity of reynanthrons (more than 90%) is excreted by the intestines in the form of pharmacologically inactive polymers. The rest of re-entantrons is absorbed, but their bioavailability is very low (about 5%). The absorbed re-entantrons are metabolized in the liver. Partially excreted by the intestine in the form of glucuronides, and partly by the kidneys, which causes the staining of urine from yellow-brown to red.
    Indications:
    Gerbion® Laxan tablets are a herbal preparation shown when:
    - Constipation caused by a change in diet and the nature of food;
    - Constipation due to hypotension and atony of the large intestine, incl. in old age, after operations and delivery.
    Contraindications:
    • Hypersensitivity to senna extract or other components of the drug;
    • spastic constipation, intestinal obstruction, strangulated hernia, perforated ulcer, gastrointestinal bleeding;
    • acute and chronic inflammatory diseases of the abdominal cavity organs (appendicitis, Crohn's disease, ulcerative colitis, proctitis and hemorrhoids (exacerbation phase));
    • abdominal pain of unknown origin;
    • metrorrhagia;
    • disturbance of water-electrolyte exchange;
    • cystitis;
    • children under 12 years;
    • pregnancy and lactation;
    • galactosemia, Lappease lactase deficiency, or glucose-galactose malabsorption syndrome.
    Carefully:
    Hepatic and / or renal failure, condition after abdominal operations, diabetes mellitus.
    Pregnancy and lactation:
    The drug is not recommended during pregnancy and lactation (insufficiently studied efficacy and safety). Active metabolites of hydroxyanthracenic glycosides penetrate into breast milk.
    Dosing and Administration:
    Inside, take before bed, after eating. Tablets should be swallowed whole, not liquid, squeezed with a small amount of liquid.
    Adults and children over 12 years of age: 1-2 tablets are recommended at bedtime.
    The dose and duration of therapy is determined individually. The maximum daily dose is -1.2 g.Without the appointment of a doctor, it is recommended to take pills no more than 1-2 weeks.
    Side effects:
    Classification of incidence of adverse events (World Health Organization (WHO)): very frequent> 1/10
    frequent from> 1/100 to <1/10
    infrequent from> 1/1000 to <1/100
    rare from> 1/10000 to <1/1000
    very rare from <1/10000, or with an unknown frequency (the frequency can not be set according to available data).
    From the gastrointestinal tract: rarely - spastic pain in the abdomen, vomiting and diarrhea, flatulence.
    Allergic reactions: rarely - skin itching, erythema and skin rash.
    From the genitourinary system: yellow or reddish-brown urine staining (due to metabolites excreted by the kidneys, this is not a pathological sign and occurs after the drug has been discontinued), proteinuria, hematuria (with prolonged use, especially in high doses).
    Metabolic disorders: hypovolemia, hypokalemia (with prolonged admission, especially in high doses, with diuretics, corticosteroids and cardiac glycosides), hyperaldosteronism.
    Other: fatigue, confusion, muscle cramps (with prolonged use).
    Overdose:
    Symptoms: abdominal pain, diarrhea, vomiting followed by loss of water and electrolytes.
    Treatment: symptomatic, replenishment of fluid and electrolytes (especially potassium) to restore electrolyte balance, which is especially important for children and the elderly.
    Interaction:
    The risk of hypokalemia increases with simultaneous administration of thiazide diuretics, corticosteroids and licorice root (Liquiritae radix).
    Hypokalemia (against the background of long-term use of the drug) increases the sensitivity of the myocardium to the action of cardiac glycosides and can potentiate the effects of antiarrhythmic drugs.
    Violates the absorption of tetracyclines.
    Special instructions:
    The effective dose of the drug is determined individually. Treatment begins with the lowest possible dose (1 tablet). The development of diarrhea is a sign of an overdose of the drug, in which case its dose should be reduced.
    With frequent or daily needs for laxatives, you should consult a doctor to determine the cause of constipation. When developing constipation, eating foods rich in plant fibers is recommended, consumption a lot of fluid and exercise.
    Excessive intake of laxatives can lead to the formation of addiction with the need for a constant increase in the doses of the drug and violations of water and electrolyte balance (in particular, hypokalemia), as well as intestinal atony. In this connection, alternation with other laxatives is recommended.
    Pigmentation of the large intestine (pseudomelanous colitis) may be a result of chronic intake of laxatives containing hydroxyanthracenic glycosides. This condition is reversible and passes after the withdrawal of such drugs.
    When taking the drug may appear staining of urine - yellow or red-brown due to metabolites, excreted by the kidneys. This is not a pathological sign and passes after the drug is discontinued on its own.
    Special instructions for excipients:
    Patients suffering from diabetes should take into account that each tablet contains 0.32 g of lactose.
    Herbion® Laxan contains lactose; therefore, the drug should not be administered to patients with galactosemia, Lappease lactase deficiency, or glucose-galactose malabsorption syndrome.
    Effect on the ability to drive transp. cf. and fur:
    The drug does not affect the ability to drive a car or other technical means.
    Form release / dosage:
    Tablets, film-coated, 15 mg.
    Packaging:
    10 tablets in a blister pack. 2 blisters together with instructions for use in a cardboard bundle.
    Storage conditions:
    Store in a dry place at a temperature of no higher than 25 ° C.
    Keep out of the reach of children.
    Shelf life:
    3 years.
    Do not use the drug after the expiration date.
    Terms of leave from pharmacies:Without recipe
    Registration number:LSR-001744/09
    Date of registration:10.03.2009
    Expiration Date:Unlimited
    Date of cancellation:2017-09-13
    The owner of the registration certificate:KRKA, dd, Novo mesto, AOKRKA, dd, Novo mesto, AO
    Manufacturer: & nbsp
    Representation: & nbspKRKA, dd, Novo mesto, AOKRKA, dd, Novo mesto, AO
    Information update date: & nbsp13.09.2017
    Illustrated instructions
      Instructions
      Up