Sennosides A and B - instructions for use, doses, side effects, contraindications

Reflex enhancement of peristalsis (irritation of intramuscular nerve plexus receptors of smooth mucous membrane), accumulation of fluid and ions in the large intestine.

Pharmacokinetics:

Absorption is low. Biotransformation of non-sucking part by hydrolysis by bacteria in the intestine to anthraquinone (active form). Elimination with urine and feces.

Indications:

Constipation of various etiologies, caused by hypotension of the gastrointestinal tract and flaccid peristalsis of the large intestine, incl. in the postoperative period, after childbirth; regulation of stool with hemorrhoids, proctitis, anal fissures; Preparation for X-ray studies.

ICD-10

XI.K55-K63.K59.0 Constipation

XV.O85-O92.O87.2 Hemorrhoids in the puerperium

XV.O20-O29.O22.4 Hemorrhoids during pregnancy

IX.I80-I89.I84.9 Hemorrhoids without complication, unspecified

IX.I80-I89.I84.8 Hemorrhoids with other complications, unspecified

IX.I80-I89.I84.7 Thrombosed hemorrhoids, unspecified

IX.I80-I89.I84.5 External hemorrhoids without complication

IX.I80-I89.I84.4 External hemorrhoids with other complications

IX.I80-I89.I84.3 External thrombosed hemorrhoids

IX.I80-I89.I84.2 Internal hemorrhoids without complication

IX.I80-I89.I84.1 Internal hemorrhoids with other complications

IX.I80-I89.I84.0 Internal thrombosed hemorrhoids

IX.I80-I89.I84 Hemorrhoids

XI.K50-K52.K51.2 Ulcerative (chronic) proctitis

XI.K55-K63.K62.6 Ulcer of anus and rectum

XI.K55-K63.K60.2 Anus fracture, unspecified

XI.K55-K63.K60.1 Chronic anal fissure

XI.K55-K63.K60.0 Acute anal fissure

XI.K55-K63.K56 Paralytic ileus and intestinal obstruction without a hernia

Contraindications:

Hypersensitivity, spastic constipation, spastic colitis, appendicitis, intestinal obstruction, abdominal pain of unclear genesis, strangulated hernia, acute inflammatory diseases of the abdominal cavity, peritonitis, gastrointestinal and uterine bleeding, cystitis, disturbances of water-electrolyte metabolism.

Carefully:

Diseases of the liver and / or kidneys, pregnancy, breast-feeding, children's age (up to 6 years), condition after abdominal operations.

Pregnancy and lactation:

The category of FDA recommendations is not defined.

Use with caution in pregnancy and lactation.

Dosing and Administration:

Inside 1 time per day in the evening before going to bed, washing down with water or some kind of drink.

Adults: the initial dose is usually 1 tab. (or 1 cube), then the dosage is selected in the range from 1/2 to 2 tables; optimal is the smallest dose necessary to obtain soft feces. In the absence of effect after a few days, the dose is increased to 2-3 tablets. If after reaching the maximum dose within 3 days of defecation does not occur, you need to see a doctor.

Children, depending on age, 1 / 3-1 / 2 doses for adults.

Side effects:

Colic pain in the abdomen, flatulence; with prolonged use (especially in high doses) - loss of electrolytes with feces (mainly potassium), albuminuria, hematuria, melanin deposition in the intestinal mucosa, nausea, vomiting, diarrhea, urine discoloration, skin rash, convulsions, vascular collapse.

Overdose:

The main adverse effect in overdose is diarrhea, leading to dehydration and loss of electrolytes. Therapy: conservative measures - increased fluid intake, the use of rehydrates. In some cases, it is necessary to compensate for the loss of fluid and electrolytes by in / in infusions of plasma substitutes.

Interaction:

Reduces the effectiveness of slowly absorbed and retard forms of drugs. While the use of thiazide diuretics, corticosteroids, licorice root drugs increases the risk of hypokalemia. With prolonged use in high doses increases the effect of cardiac glycosides and affects the effect of antiarrhythmics in connection with the possibility of hypokalemia. Violates the absorption of tetracyclines.

Special instructions:

Do not use for more than 2 weeks.

During treatment, acid urine can acquire a tan color, alkaline - a reddish color.

Instructions

Sennosides A and B (Sennosides A & B)