Active substanceGramicidin CGramicidin C
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  • Dosage form: & nbspconcentrate for solution for local and external use of alcohol 2%
    Composition:

    active substance: gramicidin C - 20 g;

    Excipients: Ethanol (ethyl alcohol 95%) - up to 1 liter.

    Description:

    The solution is from light yellow to yellow.

    Pharmacotherapeutic group:Antibiotic Polypeptide Structure
    ATX: & nbsp

    R.02.A.B.30   Gramicidin

    Pharmacodynamics:

    Antibacterial agent, has bacteriostatic (Streptococcus pneumoniae, meningococci, gonococci, causative agents of anaerobic infection) and in high concentrations bactericidal action on Streptococcus spp. and Staphylococcus spp.

    Increases the permeability of the microbial cell membrane for inorganic cations by forming a network of channels in the lipid structures of the membrane, which causes the development of osmotic instability of the cell.

    Pharmacokinetics:

    Due to low systemic absorption, pharmacokinetics data are not available.

    Indications:

    Water solution: Infectious and inflammatory diseases of the mouth and throat: angina, pharyngitis, tonsillitis, periodontitis, periodontitis, gingivitis, stomatitis, glossitis, etc.When treating and removing teeth (as an auxiliary drug).

    Aqueous and fatty solution: purulent wounds, bedsores, ulcers, burns, osteomyelitis, joint trauma, empyema, phlegmon, carbuncle, furuncle (washing, irrigation of dressings and tampons).

    Alcohol solution: pyoderma.

    In the combination therapy: infected eczema eyelids, blepharitis, meibomite (barley).

    Contraindications:

    Hypersensitivity, dermatosis (for external use), lactation.

    Carefully:

    Pregnancy.

    Dosing and Administration:

    Locally, externally.

    Rinse solution: 2-3 rinses a day.

    To prepare one rinse for adults, 10 ml of the solution (for children - 5 ml), dilute in 100 ml of drinking water.

    To prepare an aqueous solution of 2% concentrate dilute 100-200 times (adding to the contents of the bottle 5 ml - 500 ml or 1000 ml of water, and to the contents of the bottle 10 ml - 1000 or 2000 ml of water) with sterile distilled or ordinary drinking water.

    The solution is applied by irrigation or with the help of well-impregnated napkins, a sterile gauze napkin is applied from above and fixed with a gauze bandage.

    For fat preparation 2% Concentrate diluted with castor oil or fish oil or with lanolin 25-30 times (adding to the contents of the bottle 5 ml - 125 ml or 150 ml of castor oil, or fish oil, or lanolin, and to the contents of the bottle 10 ml - 250 ml or 300 ml castor oil, or fish oil, or lanolin).

    The solution is applied with the help of impregnated napkins, a sterile gauze napkin is applied from above and fixed with a gauze bandage.

    To prepare an alcohol solution, 2% concentrate is diluted 100 times with 70% ethanol (adding to the contents of the bottle 5 ml - 500 ml ethanol, and to the contents of the bottle 10 ml -1000 ml ethanol).

    With pyoderma, the skin is smeared with alcohol solution 2-3 times a day.

    Side effects:

    In some cases, allergic reactions to the components of the drug are possible.

    Contact dermatitis.

    Interaction:

    Gramicidin C enhances the effects of other antimicrobial agents of local and systemic action.

    Special instructions:An aqueous solution of gramicidin can be consumed within 3 days after preparation.
    The introduction of solutions into the vein is not allowed - hemolysis and the development of phlebitis are possible.
    Form release / dosage:

    Concentrate for the preparation of solution for local and external use [alcohol] 2%.

    Packaging:

    5 ml, 10 ml in bottles made of a glass-type glass fiber glass tube.

    Each bottle with instructions for use in a pack of cardboard.

    For 50, 150 bottles with an equal number of instructions for use in group packaging.

    Storage conditions:

    In the dark place at a temperature of 12 to 15 ° C.

    Keep out of the reach of children.

    Shelf life:

    5 years.

    Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:LSR-008631/08
    Date of registration:30.10.2008
    Expiration Date:Unlimited
    The owner of the registration certificate:UPDATE OF PFC, CJSC UPDATE OF PFC, CJSC Russia
    Manufacturer: & nbsp
    Representation: & nbspUPDATE OF PFC, CJSCUPDATE OF PFC, CJSC
    Information update date: & nbsp07.05.2017
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