Grippoflu extra for cold and flu - instructions for use, dose, side effects, contraindications

Excipients: sucrose (sugar) - 11.3027 g, citric acid - 0.71 g, sodium citrate dihydrate - 0.105 g, calcium phosphate trisubstituted (calcium phosphate) 0.050 g, titanium dioxide 0.002 g, flavor Black Currant or Raspberry ", or" Cherry ", or" Cranberry "or" Strawberry "- 0.10 g, azorubin (acidic red 2C for headlights(for berry) - 0.0003 g or flavor "Lemon" 0.10 g, dye quinoline yellow E-104 (for lemon) - 0.0003 g.

Description:

Granular powder of pink color with white impregnations and characteristic berry odor or gpowdered powder of light yellow color with the smell of lemon.

It is allowed to have crystals and easily crumbling lumps.

When the contents of the packet are dissolved in 250 ml of hot water for 2 minutes, an opalescent solution of pink color (for berry smell) or yellow color (for the smell of lemon) is formed.

Pharmacotherapeutic group:ARI and "colds" of symptoms remedy (analgesic non-narcotic agent + alpha-adrenomimetic + H1-histamine receptor blocker + vitamin)

ATX: & nbsp

N.02.B.E Anilides

N.02.B.E.51 Paracetamol in combination with other drugs, excluding psycholeptics

Pharmacodynamics:

Combined drug.

Paracetamol - a non-narcotic analgesic, affects the centers of pain and thermoregulation. Has analgesic and antipyretic effect. Reduces headache and muscle pain, fever, softens the pain in the throat.

Pheniramine - blocker H₁-gistaminovyh receptors, antiallergic, reduces rhinorrhea and lacrimation, eliminates spastic phenomena.

Phenylephrine is an adrenomimetic with a moderate vasoconstrictor effect, reduces nasal congestion and facilitates breathing through the nose.

Ascorbic acid (vitamin C) replenishes the increased need for vitamin C for colds and flu, especially in the initial stages of the disease. Increases the body's resistance to infectious diseases.

Indications:Symptomatic treatment of "catarrhal" diseases, flu, ARVI (febrile syndrome, pain syndrome, rhinorrhea).

Contraindications:

Hypersensitivity to paracetamol and other components included in the preparation; taking medicines containing substances in the preparation; simultaneous reception of tricyclic antidepressants, monoamine oxidase (MAO) inhibitors, beta-blockers; pregnancy, lactation, children's age (up to 15 years). Portal hypertension; alcoholism; hepatic and / or renal failure, deficiency of the enzyme glucose-6-phosphate dehydrogenase.

Carefully:

Pronounced atherosclerosis of the coronary arteries, arterial hypertension, thyrotoxicosis, pheochromocytoma, diabetes mellitus, bronchial asthma,chronic obstructive pulmonary disease, blood diseases, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson syndrome and Rotor syndrome), closed-angle glaucoma, prostatic hyperplasia.

Dosing and Administration:

The contents of one package pour into a glass, pour hot water, stir until completely dissolved and drink. Take the drug should be 1-2 hours after eating. Adults and children over 15 years: take one package 3-4 times a day with intervals between doses 4-6 hours. The maximum daily dose is -4 packs. The course of treatment is not more than 5 days.

Side effects:Allergic reactions (including skin rash, itching, hives, angioedema), dizziness, falling asleep, increased excitability, mydriasis; increased blood pressure, tachycardia, nausea, vomiting, epigastric pain; dry mouth; retention of urine, paresis of accommodation, increased intraocular pressure; anemia, thrombocytopenia, agranulocytosis; bronchial obstruction. With prolonged use in large doses, hepatotoxic effects, hemolytic anemia, aplastic anemia, methemoglobinaemia, pancytopenia can be observed; nephrotoxicity (papillary necrosis).

Overdose:

It is caused, as a rule, by paracetamol, manifested after taking more than 10-15 g of paracetamol. Possible: pallor of the skin, anorexia, nausea, vomiting; hepatonecrosis; increased activity of "hepatic" transaminases, an increase in prothrombin time. In cases of overdose, it is necessary to urgently consult a doctor. Treatment: gastric lavage followed by the administration of activated charcoal; symptomatic therapy, methionine administration 8 to 9 hours after an overdose and N-acetylcysteine - after 12 h.

Interaction:

The risk of hepatotoxic action of paracetamol increases with the simultaneous administration of barbiturates, diphenin, carbamazepine, rifampicin, zidovudine and other inducers of microsomal liver enzymes. Strengthens the effects of MAO inhibitors, sedatives, ethanol. Ethanol enhances the sedative effect of antihistamines. Antidepressants, antiparkinsonian and antipsychotic drugs, phenothiazine derivatives increase the risk of urinary retention, dry mouth, constipation. Glucocorticosteroids increase the risk of increased intraocular pressure. Paracetamol reduces the effectiveness of uricosuric medicines and improves the effectiveness of indirect anticoagulants. Tricyclic antidepressants enhance the sympathomimetic effect of phenylephrine, the simultaneous administration of halothane increases the risk of ventricular arrhythmia. Reduces the hypotensive effect of guanethidine, which in turn increases the alpha-adrenostimulating activity of phenylephrine.

Special instructions:During the treatment it is necessary to refrain from drinking alcohol (it is possible to develop a hepatotoxic effect).

Effect on the ability to drive transp. cf. and fur:During the treatment period it is necessary to refrain from driving motor vehicles and practicing other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:Powder for solution for oral administration.

Packaging:

For 13 g in heat-sealed bags from the combined material. For 8 or 10 bags are placed in packs of cardboard box. For 50 or 100 packets are placed in boxes of cardboard box (group packaging). The full text of the instructions for use is applied to the package.

Storage conditions:

AT dry, protected from light at a temperature of not more than 30 ° C.

Keep out of the reach of children.

Shelf life:2 years. Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-000077/08

Date of registration:18.01.2008 / 21.01.2013

Expiration Date:Unlimited

The owner of the registration certificate:MARBIOFARM, OJSC MARBIOFARM, OJSC Russia

Manufacturer: & nbsp

MARBIOFARM, OJSC Russia

Information update date: & nbsp10.05.2017

Illustrated instructions

Instructions

Grippoflu® extra cold and flu (GrippoFlu extra cold and flu)