GrippoFlu® for cold and flu (GrippoFlu® cold and flu)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceParacetamol + Phenylephrine + Pheniramine + Ascorbic acidParacetamol + Phenylephrine + Pheniramine + Ascorbic acid
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    • Dosage form: & nbspPowder for solution for oral administration
    Composition:

    Composition per package:

    Active substances:

    paracetamol 0.325 g, phenylephrine hydrochloride 0.010 g, phenylamine maleate 0.020 g, ascorbic acid 0.050 g.

    Excipients:

    sucrose (sugar) - 11.6274 g (for the flavoring "Cranberry") or 11.7074 g (for the flavor of "Malina" or "Strawberry" or "Currant"), citric acid - 0.71 g, sodium citrate dihydrate - 0.105 grams, flavoring "Cranberry" 0.1 g or flavor "Malina" or "Strawberry" or "Currant" 0.02 g, calcium phosphate 0.05 g, titanium dioxide 0.002 g, dye quinoline yellow E-104 -0,0003 g, azorubin dye-0,0003 g.

    Description:Granulated powder of pink color with white impregnations and a characteristic berry odor. Colorless, shiny crystals and easily crumbling lumps are allowed. When the contents of the packet are dissolved in 200 ml of hot water for 2 minutes, an opalescent solution of pink color is formed.
    Pharmacotherapeutic group:ARI and "colds" of symptoms remedy (analgesic non-narcotic agent + alpha-adrenomimetic + H1-histamine receptor blocker + vitamin)
    ATX: & nbsp

    N.02.B.E   Anilides

    N.02.B.E.51   Paracetamol in combination with other drugs, excluding psycholeptics

    Pharmacodynamics:

    Combined drug.

    Paracetamol - a non-narcotic analgesic, affects the centers of pain and thermoregulation. Has analgesic and antipyretic effect. Reduces headache and muscle pain, fever, softens the pain in the throat.

    Phenyramin - blocker H1-gistaminovyh receptors, antiallergic, reduces rhinorrhea and lacrimation, eliminates spastic phenomena.

    Phenylephrine is an adrenomimetic with a moderate vasoconstrictor effect, reduces nasal congestion and facilitates breathing through the nose.

    Ascorbic acid - is involved in the regulation of oxidation-reduction processes, carbohydrate metabolism, blood clotting, increases the body's resistance to infections, reduces vascular permeability. It improves paracetamol tolerance and lengthens its action.

    Indications:Infectious and inflammatory diseases (acute respiratory infections, influenza) accompanied by fever, chills and fever, headache, runny nose, stuffy nose, sneezing and muscle aches.
    Contraindications:Arterial hypertension, diabetes mellitus, closed-angle glaucoma, severe liver, kidney, heart, thyroid, lung (including bronchial asthma), bladder, stomach and duodenum ulcer, pancreatic diseases, urinary difficulty in prostatic adenoma, blood system diseases, deficiency enzyme glucose-6-phosphate dehydrogenase, increased sensitivity to individual components of the drug. Pregnancy and lactation. Children under 12 years.
    Carefully:

    Congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor syndrome), closed-angle glaucoma, prostatic hyperplasia.

    Dosing and Administration:Dissolve the contents of one packet in 1 glass of boiled hot water; to use in a hot kind. You can add sugar to taste. Repeated dose can be taken every 4 hours, but not more than 3 doses of the drug within 24 hours. Duration of admission as an antipyretic agent - no more than 3 days.
    Side effects:Allergic reactions (skin rash, itching, hives, angioedema), nausea, epigastric pain, anemia, thrombocytopenia, agranulocytosis. Increased excitability, dizziness, increased blood pressure, palpitation, falling asleep. Increased intraocular pressure, dry mouth, urinary retention. With prolonged use in large doses, hepatotoxic and nephrotoxic effects (renal colic, glucosuria, interstitial nephritis, papillary necrosis), hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia are possible.
    Overdose:Symptoms (due to paracetamol): pallor of the skin, decreased appetite, nausea, vomiting; hepatonecrosis. Toxic effect in adults is possible after taking more than 10-15 g of paracetamol: increased activity of "liver" transaminases,increased prothrombin time (12-48 h after administration); a detailed clinical picture of liver damage manifests itself after 1-6 days. Rarely, liver failure develops at a lightning speed and can be complicated by renal insufficiency (tubular necrosis).
    Treatment: introduction of donators     SH -groups and precursors of glutathione-methionine synthesis 8-9 hours after an overdose and N -acetylcysteine ​​after 12 hours. The need for additional therapeutic measures is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.
    Interaction:Strengthens the effects of monoamine oxidase inhibitors, sedatives, ethanol. Ethanol enhances the sedative effect of antihistamines. Antidepressants, antiparkinsonian and antipsychotic drugs, phenothiazine derivatives increase the risk of urinary retention, dry mouth, constipation. Glucocorticosteroids increase the risk of increased intraocular pressure. Paracetamol reduces the effectiveness of uricosuric medicines and improves the effectiveness of indirect anticoagulants.Tricyclic antidepressants enhance the sympathomimetic effect, the simultaneous administration of halothane increases the risk of ventricular arrhythmia. Reduces the hypotensive effect of guanethidine, which in turn increases the alpha-adrenostimulating activity of phenylephrine.
    Special instructions:

    Without the doctor's instructions, the drug should not be used by pregnant women and nursing mothers, as well as patients undergoing treatment with other medicines. In particular monoamine oxidase inhibitors.

    The drug is not prescribed for children under the age of 12 years.

    When taking the drug is not recommended to drink alcohol, drugs that depress the central nervous system (hypnotics, tranquilizers, etc.).

    Effect on the ability to drive transp. cf. and fur:When taking the drug is not recommended to drive or other mechanisms.
    Form release / dosage:

    Powder for solution for oral administration.

    Packaging:Powder 13.0 g in a bag of material combined. By 10 packages in packs of cardboard or 100 packages in boxes of cardboard.
    Storage conditions:

    In dry, the dark place at a temperature of not more than + 30 ° C.

    Keep out of the reach of children.

    Shelf life:2 years. Do not use after the date specified on the package.
    Terms of leave from pharmacies:Without recipe
    Registration number:LS-000905
    Date of registration:10.06.2010 / 06.11.2013
    Expiration Date:Unlimited
    The owner of the registration certificate:MARBIOFARM, OJSC MARBIOFARM, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp10.05.2017
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