Idebenon (Idebenone)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceIdebenonIdebenon
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  • Idebenon
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    • Dosage form: & nbspcapsules
    Composition:
    1 capsule contains:
    active substance: idebenon 30 and 45 mg;
    Excipients: calcium hydrophosphate dihydrate, pregelatinized starch, macrogol (polyethylene glycol), magnesium stearate, microcrystalline cellulose;
    hard gelatin capsule number 1:
    housing: titanium dioxide, iron oxide yellow oxide, gelatin;
    cap: titanium dioxide, iron dye oxide black, iron oxide red dye, iron oxide oxide yellow, gelatin; capsule hard gelatinous N ° 0:
    housing: titanium dioxide, iron oxide yellow oxide, gelatin;
    cap: titanium dioxide, iron oxide ferric oxide, iron oxide red dye, iron oxide oxide yellow, gelatin.
    Description:
    Dosage of 30 mg: hard gelatin capsules number 1, body - yellow, cap - brown, the contents of capsules - a mixture of granules and a powder of yellow or yellow-orange color. Presence of lumps is allowed.
    Dosage of 45 mg: hard gelatin capsules number 0, body - yellow, cap - light brown.The contents of the capsules are a mixture of granules and a powder of yellow or yellow-orange color. Presence of lumps is allowed.
    Pharmacotherapeutic group:Nootropic remedy
    ATX: & nbsp

    N.06.B.X.13   Idebenon

    Pharmacodynamics:Nootropic agent, has a metabolic and trophic effect. Increases metabolic processes in the brain, improves blood circulation and oxygenation of brain tissue, promotes the excretion of lactate; increases the intensity and speed of neurophysiological reactions of brain structures. Slowing down lipid peroxidation, protects the membranes of neurons and mitochondria from damage. Antidepressant action occurs no earlier than 14 days later.
    Pharmacokinetics:
    Suction: Absorption - fast and complete. The maximum concentration in the blood plasma is reached after 4 hours.
    Distribution: penetrates the blood-brain barrier in significant quantities and is distributed in the brain tissues. Do not cumulate. Excretion: is excreted by the kidneys.

    Indications:
    - psychoorganic syndrome on the background of cerebral circulation and age-related involuntary changes in the brain;
    cerebroasthenic disorders of vascular, traumatic, psychogenic (neurasthenia) etiology: impaired memory and / or attention, decreased intellectual productivity and general activity, emotional instability;
    - asthenic and asthenodepressive syndrome, moderately expressed depressive syndrome;
    - dizziness, noise in the ears (manifestations of vestibular insufficiency).
    Contraindications:Hypersensitivity, chronic renal failure. Due to the lack of clinical data, Idebenon is contraindicated in children under 18 years of age.
    Carefully:Pregnancy, lactation.
    Pregnancy and lactation:Carefully
    Dosing and Administration:It is applied inside, 30 mg 2-3 times a day after meals, the last reception - up to 17 hours. The course of treatment - 1,5-2 months; if necessary - spend 2-3 courses per year.
    Side effects:
    From the side of the central nervous system, rarely (> 1/10 000, <1/1000): violation of falling asleep, mental agitation, headache.
    From the digestive system, rarely (> 1/10 000, <1/1000): indigestion.
    Allergic reactions, very rarely (<1 / 10,000) - skin rash.

    Overdose:
    Symptoms: increased severity of dose-related side effects.
    Treatment: if necessary appoint Activated carbon and conduct symptomatic therapy.

    Special instructions:Do not take patients whose profession is associated with driving motor vehicles and other potentially dangerous activities that require increased concentration and speed of psychomotor reactions.
    Effect on the ability to drive transp. cf. and fur:Do not take patients whose profession is associated with driving motor vehicles and other potentially dangerous activities that require increased concentration and speed of psychomotor reactions.
    Form release / dosage:
    Capsules of 30 and 45 mg.
    Packaging:
    For 10 or 15 capsules in a contour mesh box made of polyvinylchloride film and aluminum foil printed lacquered.
    For 1, 2, 3, 6 or 12 contour cell packs of 10 capsules or 1, 2, 4 or 8 contour cell packs of 15 capsules with instructions for use are placed in a pack of cardboard.
    Storage conditions:In a dry, protected from light place at a temperature of no higher than 25 ° C. Keep out of the reach of children.
    Shelf life:
    2 years.
    Do not use after the expiration date.
    Terms of leave from pharmacies:On prescription
    Registration number:LP-000058
    Date of registration:29.11.2010
    The owner of the registration certificate:CANONFARMA PRODUCTION, CJSC CANONFARMA PRODUCTION, CJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp29.11.2010
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