Do not administer the drug intravenously!
Immunoglobulin is injected intramuscularly into the upper outer quadrant of the gluteus muscle or to the external surface of the thigh.
Before injection, the ampoule with the drug is kept for 2 hours at room temperature (20 ± 2 ° C). Opening of ampoules and the procedure of administration are carried out with strict adherence to aseptic and antiseptic rules. The drug in the opened ampoule is not subject to storage. The preparation is not suitable for use in ampoules with broken integrity or marking, with a change in physical properties (color change, cloudiness of solution, the presence of unbreakable flakes), in the event of a violation of the temperature storage regime.
The dose of the drug for prevention or treatment is calculated by volume, depending on the patient's body weight.
Prevention
For the purpose of prevention, the drug is administered intramuscularly once at a rate of 0.1 ml per 1 kg of body weight.
Table of prophylactic dosages of immunoglobulin against CE
| Body mass | Injection volume |
| 5 kg | 0.5 ml |
| 10 kg | 1.0 ml |
| 20 kg | 2.0 ml |
| 30 kg | 3.0 ml |
| 40 kg | 4.0 ml |
| 50 kg | 5.0 ml |
| 60 kg | 6.0 ml |
| 70 kg | 7.0 ml |
| 80 kg | 8.0 ml |
Introduction after a tick bite
The drug should be administered at the earliest possible time from the date of the alleged infection, no later than the 4th day after the tick bite.
For the purpose of emergency prophylaxis, the drug is administered in a single dose not vaccinated against tick-borne encephalitis or receiving an incomplete vaccination course that noted the sucking of ticks in endemic areas, as well as suspected of laboratory infection with the CE virus.
In cases of increased risk of infection (infection of sucking tick, multiple bites or simultaneous suction of several mites), the drug is administered in a single dose and inoculated patients.
Children under 12 years - 1 ml; 12-16 years old - 2 ml; over 16 years old - 3 ml.
In the case of a new tick bite, it is possible to repeat the use of the drug at the same dose one month after the first administration.
Introduction before the tick bite
The drug can be used before probable contact with tick-borne encephalitis virus - a bite in the endemic area (pre-exposure prevention). The protective effect manifests itself in 24-48 hours and lasts about 4 weeks. To maintain immunological protection in case of danger of infection, it is recommended to repeat the introduction of immunoglobulin against tick-borne encephalitis after 4 weeks.
Treatment
For therapeutic purposes, immunoglobulin is administered at the earliest possible time after the onset of the disease at various dosages, depending on the body weight and clinical form of infection, the severity of the course and the period of the disease.
Patients with erased and abortive forms of CE (febrile forms of infection), immunoglobulin is administered daily in a single dose of 0.1 ml / kg body weight for 3-5 days before the regression of common infection symptoms (improvement in general condition, disappearance of fever). The average course dose for an adult is at least 21 ml of the drug.
With meningeal form of CE The drug is used daily in a single dose of 0.1 ml / kg of body weight twice a day at intervals of 10-12 hours for at least 5 days until the patient's general condition improves according to objective indicators (disappearance of fever, regression of common infectious symptoms, stabilization or reduction of meningeal symptoms). The average course of an immunoglobulin for an adult is at least 70 ml.
Patients with focal forms of tick-borne encephalitis depending on the severity of the disease, the drug is administered daily in a single dose of 0.1 ml / kg of body weight 2-3 times a day at intervals of 8-12 hours for at least 5-6 days before the temperature decreases and the neurological symptoms stabilize.The average course dose for an adult is on average 80 to 130 ml of immunoglobulin.
In extremely severe disease, a single dose of the drug can be increased to 0.15 ml / kg body weight.
If specific therapy was not performed for patients with meningeal and focal forms of CE for any reasons, it is possible to administer immunoglobulin at the apyrexia stage of the acute period of the disease for 5-6 days in a single dose of 0.1 ml / kg of body weight every 10 -12 hours.
In the case of a two-wave flow of tick-borne encephalitis, the drug is used repeatedly according to the scheme of treatment of meningeal or focal forms depending on the nature of the clinical manifestations.