Enter intramuscularly, in the upper outer quadrant of the gluteus muscle or in the external surface of the thigh. Do not administer the drug intravenously!
Before the injection, the ampoule with the drug is kept for 2 hours at room temperature (20 ± 2) ° C. Opening of ampoules and the procedure of administration are carried out with strict adherence to aseptic and antiseptic rules. To prevent the formation of foam, the drug is drawn into the syringe with a needle with a wide lumen.
The drug in the opened ampoule is not subject to storage.
The dose of immunoglobulin and the frequency of its administration depend on the indications for use.
Prevention
Prophylaxis before tick bite
The drug can be used before probable contact with tick-borne encephalitis virus - tick bite in the endemic area (pre-exposureprevention). The protective effect manifests itself in 24-48 hours and lasts about 4 weeks. To maintain immunological protection in case of danger of infection, it is recommended to repeat the administration of immunoglobulin after 4 weeks.
For the purpose of prevention, the drug is administered intramuscularly once at a rate of 0.1 ml per 1 kg of body weight.
Table of prophylactic dosages of immunoglobulin against tick-borne encephalitis
| Body weight, kg | 5 | 10 | 20 | 30 | 40 | 50 | 60 | 70 | 80 |
| Injection volume, ml | 0,5 | 1,0 | 2,0 | 3,0 | 4,0 | 5,0 | 6,0 | 7,0 | 8,0 |
Prophylaxis after tick bite
For the purpose of emergency prophylaxis, the drug is administered primarily unvaccinated against tick-borne encephalitis or who received an incomplete vaccination course that noted tick sucking in endemic areas, as well as suspected laboratory infection with tick-borne encephalitis virus.
In cases of increased risk of infection (infection of sucking tick, multiple bites or simultaneous suction of several mites), the drug is administered to vaccinated individuals. Children under 12 years - 1 ml; 12-16 years old - 2 ml; from 16 years and older - 3 ml.
In the case of a new contact with ticks, it is possible to reapply the drug one month after the first administration.
In all cases, the drug should be administered at the earliest possible time from the date of the alleged infection, no later than 4 days after the tick bite.
Treatment
With therapeutic purpose, immunoglobulin is administered at the earliest possible time after the onset of the disease in various dosages, depending on the body weight, the clinical form of the infection, the severity of the course and the period of the disease.
- Patients with erased and abortive forms of tick-borne encephalitis (febrile forms of infection), immunoglobulin is administered daily in a single dose of 0.1 ml / kg of body weight, for 3-5 days before the regression of common infectious symptoms (general improvement, disappearance of fever). The average course dose for an adult is at these forms not less than 21.0 ml of the drug.
- When meningeal form of tick-borne encephalitis the drug is applied daily in a single dose of 0.1 ml / kg of body weight with an interval of 10-12 hours for at least 5 days until the patient's overall condition improves according to objective indicators (disappearance of fever, regression of common infectious symptoms, stabilization and reduction of meningeal symptoms ). The average course of an immunoglobulin for an adult is at a meningeal form of infection of at least 70.0 ml.
- Patients with focal forms of tick-borne encephalitis, depending on the severity of the disease, the drug is administered daily in a single dose of 0.1 ml / kg body weight with an interval of 8-12 hours for at least 5-6 days before the temperature decreases and the neurological symptoms stabilize. The average course dose for an adult patient is on the average not less than 80.0-130.0 ml of immunoglobulin.
In extremely severe disease, a single dose of the drug can be increased to 0.15 ml / kg body weight.
If no specific therapy was performed in patients with meningeal and focal forms of tick-borne encephalitis for any reason, it is possible to administer immunoglobulin at the acute stage of the apyrexia of the acute disease for 5-6 days in a single dose of 0.1 ml / kg body weight after 10-12 hours.
In the case of a two-wave flow of tick-borne encephalitis, the drug is used repeatedly according to the scheme of treatment of meningeal or focal forms depending on the nature of the clinical manifestations.