Immunoglobulin is injected intramuscularly into the upper outer quadrant of the gluteus muscle or to the external surface of the thigh. Do not administer the drug intravenously.
The dose of immunoglobulin and the frequency of its administration depend on the indications for use.
Prevention
Introduction before the tick bite
The drug can be used before a probable contact with the virus CE - tick bite in an endemic area (pre-exposure prevention). The protective effect manifests itself in 24-48 hours and lasts about 4 weeks. To maintain immune protection, in case of danger of infection, it is recommended to repeat the administration of immunoglobulin after 4 weeks.
For the purpose of prevention, the drug is administered intramuscularly once at a rate of 0.1 ml per 1 kg of body weight.
Introduction after a tick bite
For the purpose of emergency prophylaxis, the drug is administered primarily unvaccinated against CE or who received an incomplete vaccination course that noted tick sucking in endemic areas, as well as suspected laboratory infection with CE virus.
In cases of increased risk of infection (infection of sucking tick, multiple bites or simultaneous suction of several mites), the drug is administered to vaccinated individuals.
In the case of a new contact with ticks, it is possible to reapply the drug one month after the first administration.
In all cases, the drug should be administered at the earliest possible time from the date of the alleged infection, no later than the fourth day after the tick bite.
Prophylactic dosages of immunoglobulin against TB
| Body mass | 5 kg | 10 kg | 20 kg | 30 kg | 40 kg | 50 kg | 60 kg | 70 kg | 80 kg |
| Scope injections | 0.5 ml | 1.0 ml | 2.0 ml | 3.0 ml | 4.0 ml | 5.0 ml | 6.0 ml | 7.0 ml | 8.0 ml |
Treatment
With therapeutic purpose, immunoglobulin is administered at the earliest possible time after the onset of the disease in various dosages, depending on the body weight, the clinical form of the infection, the severity of the course and the period of the disease.
- B(with febrile forms of infection), immunoglobulin is administered daily in a single dose of 0.1 ml / kg of body weight, for 3-5 days before the regression of common infectious symptoms (general improvement, disappearance of fever).The average course dose for an adult is at these forms not less than 21.0 ml of the drug.
- PIn the meningeal form of CE, the drug is applied daily in a single dose of 0.1 ml / kg of body weight at intervals of 10-12 hours for at least 5 days until the patient's general condition improves according to objective indicators (disappearance of fever, regression of common infectious symptoms, stabilization and reduction of meningeal symptoms). The average course of an immunoglobulin for an adult is at a meningeal form of infection of at least 70.0 ml.
- Bwith focal forms of tick-borne encephalitis, depending on the The severity of the disease is given daily in a single dose of 0.1 ml / kg of body weight with an interval of 8-12 hours for at least 5-6 days before the temperature decreases and the neurological symptoms stabilize. The average course dose for an adult patient is on the average not less than 80.0-130.0 ml of immunoglobulin.
In extremely severe disease, a single dose of the drug can be increased to 0.15 ml / kg body weight.
If patients with meningeal and focal forms of CE for any reason in the febrile stage of the disease, specific therapy was not performed,it is possible to administer the immunoglobulin and at the apyrexia stage of the acute period of the disease with a therapeutic purpose for 5-6 days in a single dose of 0.1 ml / kg of body weight in 10-12 hours.
In the case of a two-wave CE course, the drug is used repeatedly according to the treatment regimen for meningeal or focal forms, depending on the nature of the clinical manifestations.