Immunoglobulin is injected intramuscularly into the upper outer quadrant of the buttockushcs or in the outer surface of the thigh. Before the injection, the ampoule with the drug is kept for 2 hours at a temperature of 18 to 22 ° C. Opening of ampoules and the procedure of administration are carried out with strict adherence to aseptic and antiseptic rules.
The drug in the opened ampoule is not subject to storage.The preparation is not suitable for use in ampoules with broken integrity or marking, with a change in physical properties (color change, cloudiness of solution, the presence of unbreakable flakes), in the event of a violation of the temperature storage regime.
The dose of immunoglobulin and the frequency of its administration depend on the indications for use.
Prevention
FROM The purpose of prevention of the drug is administered once for 0.1 ml per 1 kg of body weight.
Table of prophylactic dosages of immunoglobulin against CE
| Body mass | Injection volume |
| 5 kg | 0.5 ml |
| 10 kg | 1 ml |
| 20 kg | 2 ml |
| 30 kg | 3 ml |
| 40 kg | 4 ml |
| 50 kg | 5 ml |
| 60 kg | 6 ml |
| 70 kg | 7 ml |
| 80 kg | 8 ml |
Introduction after a tick bite
The drug should be administered at the earliest possible time from the date of the alleged infection, no later than the 4th day after the tick bite.
For the purpose of emergency prevention, the drug is administered in a single dose not vaccinated against tick-borne encephalitis or receiving an incomplete vaccination course that noted the sucking of ticks in endemic areas, as well as suspected laboratory infection with the CE virus.
In cases of increased risk of infection (infection of sucking tick, multiple bites or simultaneous suction of several mites), the drug is administered in a single dose and vaccinated persons.
In the case of a new tick bite, after a month after the first injection, the drug is administered again in the same dose.
Introduction before the tick bite
The drug can be used before probable contact with tick-borne encephalitis virus - tick bite in the endemic area (pre-exposure prophylaxis). The protective effect manifests itself in 24-48 hours and lasts about 4 weeks. At the end of this period, in case of danger of infection, it is recommended to repeat the administration of immunoglobulin after 4 weeks.
Treatment
With a therapeutic purpose, the immunoglobulin is administered at the earliest possible time after the onset of the disease:
- patients with erased and abortive forms of CE (febrile forms of infection), immunoglobulin is administered daily in a single dose of 0.1 ml / kg of body weight, 3-5 days before the regression of common infectious symptoms (general improvement, disappearance of fever). The average course dose for an adult is at least 21 ml of the drug;
- with meningeal form of CE the drug is applied daily in a single dose of 0.1 ml / kg of body weight twice a day at intervals of 10-12 hours for at least 5 days until the patient's overall condition improves according to objective indicators (disappearance of fever, regression of common infectious symptoms, stabilization and reduction of meningeal symptoms).The average course of an immunoglobulin for an adult is at least 70 ml;
- patients with focal forms of tick-borne encephalitis depending on the severity of the disease, the drug is administered daily in a single dose of 0.1 ml / kg of body weight 2-3 times a day at intervals of 8-12 hours for 5-6 days before the temperature decreases and the neurological symptoms stabilize. The average course for an adult patient is an average of 80 to 130 ml of immunoglobulin.
In extremely severe disease, a single dose of the drug can be increased to 0.15 ml / kg body weight.
If patients with meningeal and focal forms of CE for any reasons in the fever stage of the disease did not undergo specific therapy, it is possible to administer the immunoglobulin at the apyrexia stage of the acute period of the disease for 5-6 days in a single dose of 0.1 ml / kg of body weight via 10-12 hours.
In the case of a two-wave flow of tick-borne encephalitis, the drug is used repeatedly according to the scheme of treatment of meningeal or focal forms depending on the nature of the clinical manifestations.