Cardion - instructions for use, dose, side effects, contraindications

Structural analogue of gamma-butyrobetaine. Meldoney inhibits gamma-butyrobetaine hydroxylase, which leads to a decrease in the synthesis of carnitine, restriction of transport to cells of long chain fatty acids, and prevents the accumulation of activated forms of unoxidized fatty acids - derivatives of acylcarnitine and acylcoenzyme A. Under conditions of ischemia, restores the equilibrium of oxygen delivery and consumption, activates glycolysis; prevents transport disruption and reduction in the level of adenosine triphosphate (ATP). As a result of a decrease in the concentration of carnitine, gamma-butyrobetaine, which has vasodilating properties, is synthesized intensively.

In the case of acute ischemic damage, the myocardium slows the formation of the necrotic zone, shortens the rehabilitation period. In chronic heart failure (CHF) increases tolerance to physical activity. When angina pectoris reduces the frequency of attacks. In acute and chronic ischemic disorders of cerebral circulation improves blood circulation in the ischemic focus, promotes redistribution of blood in favor of the ischemic site. Effective in the case of vascular and dystrophic pathology of the fundus. It has a tonic effect on the central nervous system, it helps to eliminate functional disorders of the somatic and vegetative parts of the nervous system in patients with chronic alcoholism during the period of abstinence. Reduces the severity of symptoms of mental and physical overstrain.

Pharmacokinetics:

After intravenous administration, the maximum concentration of the drug in the blood plasma is reached immediately after its administration. There are no data on the bioavailability of the drug after intramuscular injection. Metabolized in the body with the formation of two major metabolites, which are excreted by the kidneys.The half-life is 3-6 hours.

Indications:

In complex therapy: ischemic heart disease (angina pectoris, myocardial infarction), chronic heart failure, cardialgia against the background of dyshormonal myocardial dystrophy.

In complex therapy: disorders of cerebral circulation (ischemic stroke, cerebrovascular insufficiency).

In complex therapy: Acute circulatory disorder in the retina, hemophthalmus and retinal hemorrhages of varying etiology, thrombosis, central retinal vein and its branches, retinopathy of various etiologies (including diabetic and idiopathic) - only for administration parabulbarly.

Reduced performance, physical overexertion (including athletes).

An abstinent alcoholic syndrome (as part of complex specific therapy).

Contraindications:

Hypersensitivity to the drug; increased intracranial pressure (with violation of venous outflow and intracranial tumors); pregnancy, lactation, age under 18 years.

Carefully:

Diseases of the liver and / or kidney.

Pregnancy and lactation:

Contraindicated use of the drug during pregnancy and during breastfeeding.

Dosing and Administration:

Due to the possible exciting effect of the drug is recommended to use in the morning.

Angina pectoris and myocardial infarction (as part of combination therapy); intravenously (iv) 0.5-1 g (5-10 ml solution for injection 100 mg / 1 ml) once a day, then switch to taking the drug inside.

Chronic heart failure (as part of a combination therapy): iv 0.5-1 g (5-10 ml solution for injection) once a day; course of treatment - 10-14 days, then switch to taking the drug inside.

Cardialgia against dyshormonal myocardial dystrophy: in / in 0.5-1 g (5-10 ml solution for injection) once a day or in / m 0.5 g 1-2 times a day; course of treatment - 10-14 days, then they switch to taking the drug inside.

Violation of cerebral circulation (as part of combination therapy): acute phase - IV infusion of 500 mg (5 ml solution for injection) once a day for 10 days, then it is possible to switch to oral administration; chronic disorders of cerebral circulation: in / m 500 mg (5 ml solution for injection) once a day; course of treatment 10-14 days, then it is possible to switch to taking the drug inside.

Vascular pathology of the fundus and retinal dystrophy (in complex therapy): parabulbarno for 0.5 ml solution for injection for 10 days.

Physical and mental overloads: in / in 0.5 g (5 ml solution for injection) once a day; course of treatment - 10-14 days. If necessary, repeat the course after 2-3 weeks.

An abstinent alcoholic syndrome: in / in 500 mg (5 ml solution for injection) 2 times a day; course of treatment - 7-10 days.

Side effects:

Rarely - allergic reactions (redness, skin rash, itching, swelling), dyspepsia, tachycardia, decrease or increase in blood pressure, agitation.

Very rarely - eosinophilia, general weakness.

Overdose:

Symptoms: lowering blood pressure, headache, tachycardia, dizziness, general weakness.

Treatment: symptomatic.

Interaction:

Strengthens the coronarodilating and hypotensive drugs, cardiac glycosides. In view of the possible development of moderate tachycardia and arterial hypotension, caution should be exercised when combined with nitroglycerin, nifedipine, alpha-blockers, hypotensive drugs and peripheral vasodilators.

You can combine with antianginal drugs, anticoagulants, antiaggregants, antiarrhythmics, diuretics, bronchodilators.

Special instructions:

With caution, use the drug for liver and / or kidney disease, especially for a long time.

Many years of experience in the treatment of acute myocardial infarction and unstable angina in the cardiology departments shows that meldoon is not a drug of the first series in acute coronary syndrome and its use is not an urgent need.

Effect on the ability to drive transp. cf. and fur:

There is no data on the adverse effects of meldonia on the rate of psychomotor reactions.

Form release / dosage:Solution for injection 100 mg / ml.

Packaging:

5 ml into neutral glass ampoules. 5 ampoules per circuit cell packaging made of polyvinylchloride film or polyvinyl chloride film and aluminum foil printed lacquered.

1, 2 contour mesh Packing together with instructions for use and a knife for opening ampoules (in case of using ampoules with a dot or a ring of breakage, the knife is not inserted) is placed in a pack of cardboard.

Storage conditions:

At a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

4 years. Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LS-001951

Date of registration:01.12.2011 / 10.10.2016

Expiration Date:Unlimited

The owner of the registration certificate:NIZHFARM, JSC NIZHFARM, JSC Russia

Manufacturer: & nbsp

MOSCOW ENDOCRINE FACTORY, FSUE Russia

Representation: & nbspNizhpharm, JSCNizhpharm, JSCRussia

Information update date: & nbsp11.12.2017

Illustrated instructions

Instructions

Cardionate® (Cardionate)