Active substanceMeldoneyMeldoney
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  • Dosage form: & nbspinjection
    Composition:

    Active substance: meldonia dihydrate (in terms of dihydrate without adsorbed moisture) - 100.0 mg.

    Excipient: water for injection - up to 1.0 ml.
    Description:Transparent colorless liquid.
    Pharmacotherapeutic group:Metabolic means
    ATX: & nbsp

    C.01.E.B.22   Meldoney

    C.01.E.B   Other drugs for the treatment of heart disease

    Pharmacodynamics:

    Analog gamma-butyrobetaine, inhibits gamma butirobetaingidroksilazu, reduces the synthesis of carnitine and transportation of long chain fatty acids across cell membranes and prevents the accumulation of cells in the activated forms of unoxidized fatty acids - acylcarnitine derivatives and atsilkofermenta A. ischemia restores the balance of oxygen delivery processes and its use in cells, prevents disruption of the transport of adenosine triphosphate (ATP); simultaneously, it activates glycolysis, which proceeds without additional consumption of oxygen. As a result of a decrease in the concentration of carnitine, gamma-butyrobetaine, which has vasodilating properties, is synthesized intensively.The mechanism of action determines the variety of its pharmacological effects: increasing efficiency, reducing the symptoms of mental and physical overstrain, the activation of tissue and humoral immunity, cardioprotective action. In the case of acute ischemic damage, the myocardium slows the formation of the necrotic zone, shortens the rehabilitation period. With heart failure increases myocardial contractility, increases exercise tolerance, reduces the incidence of angina attacks. In acute and chronic ischemic disorders of cerebral circulation improves blood circulation in the ischemic focus, promotes redistribution of blood in favor of the ischemic site. Effective in the case of vascular and dystrophic pathology of the fundus. Characteristic is also a tonic effect on the central nervous system (CNS), the elimination of functional disorders of somatic and autonomic nervous systems in patients with alcoholism during the period of abstinence.

    Pharmacokinetics:

    Metabolized in the body with the formation of two major metabolites, which are excreted by the kidneys.

    Indications:

    Mental and physical overloads (incl.athletes).

    As part of complex therapy:

    - ischemic heart disease (angina pectoris, myocardial infarction), chronic heart failure and dyshormonal cardiomyopathy;

    - disorders of blood supply to the brain (stroke, cerebrovascular insufficiency);

    - acute circulatory disturbance in the retina, hemophthalmia and hemorrhage into the retina of various etiologies, thrombosis of the central vein of the retina and its branches, retinopathy of various etiologies (including diabetic and hypertensive);

    - chronic alcoholism.

    Contraindications:

    Hypersensitivity, increased intracranial pressure (with violation of venous outflow and intracranial tumors), pregnancy, lactation, age under 18 years.

    Carefully:

    Patients with chronic liver and kidney disease with prolonged use of meldonia should be careful.

    Dosing and Administration:

    Meldonium-ESCOM is administered intravenously, intramuscularly, parabulbar. Mental and physical overloads (including athletes) intravenously by 500 mg once a day. The course of treatment is 10-14 days. If necessary, repeat the treatment after 2-3 weeks.Cardiovascular diseases - intravenously struino, 0.5-1 g once a day, after which it is prescribed inside.

    Violation of cerebral circulation: the acute phase of cerebrovascular pathology - intravenously, 500 mg once a day for 10 days, after which it is prescribed inside. The course of treatment - 2-3 weeks. Chronic disorders of cerebral circulation: intramuscular 500 mg once a day, preferably in the morning. The course of treatment - 2-3 weeks. Vascular pathology and dystrophic retinal diseases: parabulbarno injected into 0.5 ml of 100 mg / ml solution for 10 days.

    Chronic alcoholism - intravenously on 500 mg 2 times a day. The course of treatment is 7-10 days.

    Side effects:

    Rarely - allergic reactions (reddening, rashes, itching, swelling), as well as dyspeptic phenomena, tachycardia, changes in blood pressure, agitation.

    Interaction:

    Meldonium-ESCOM can be combined with antianginal drugs, anticoagulants, antiaggregants, antiarrhythmics, cardiac glycosides, diuretics, bronchodilators.

    Because the meldoon can cause mild tachycardia and a decrease in blood pressure, caution should be exercised in combining meledonia with hypotensive drugs and peripheral vasodilators. Meldoney can enhance the effects of cardiac glycosides, nitroglycerin, nifedipine, beta-blockers (propranolol, carvedilol, metoprolol, atenolol, bisoprolol, pindolol, sotalol, nebivolol).

    Form release / dosage:

    Solution for injection 100 mg / ml.

    Packaging:

    For 5 ml of the drug in the ampoules of neutral-protective light glass brand SNS-1 or neutral glass grade NS-3.

    10 ampoules, together with instructions for medical use and scarifier ampullum, are placed in a cardboard bundle with cardboard partitions or 5 or 10 ampoules are placed in a contour cell box made of a polyvinyl chloride film.

    When using ampoules with a notch or a fracture ring, the scarifier is not inserted.

    For 1 or 2 contour acupule packs, along with instructions for medical use, put in a pack of cardboard.

    Storage conditions:

    In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

    Shelf life:

    4 years. Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-010452/09
    Date of registration:22.12.2009
    Expiration Date:Unlimited
    The owner of the registration certificate:ESKOM NPK, OAO ESKOM NPK, OAO Russia
    Manufacturer: & nbsp
    Information update date: & nbsp23.04.2018
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