Meldoney (Meldonium)

Analog gamma-butyrobetaine, inhibits gamma butirobetaingidroksinazu, reduces the synthesis of carnitine and transportation of long chain fatty acids across cell membranes and prevents the accumulation of cells in the activated forms of unoxidized fatty acids - acylcarnitine derivatives and atsilkoenzima A. ischemia restores the balance of oxygen delivery processes and its use in cells, prevents disruption of ATP transport; simultaneously activates glycolysis (which proceeds without additional oxygen consumption. By lowering the carnitine concentration intensively synthesized gamma-butyrobetaine possesses vasodilating properties.The mechanism of action determines the variety of its pharmacological effects: increasing efficiency, reducing the symptoms of mental and physical overstrain, the activation of tissue and humoral immunity, cardioprotective action. In the case of acute ischemic damage, the myocardium slows the formation of the necrotic zone, shortens the rehabilitation period. With heart failure increases myocardial contractility, increases exercise tolerance, reduces the incidence of angina attacks. In acute and chronic ischemic disorders of cerebral circulation improves blood circulation in the ischemic focus, promotes redistribution of blood in favor of the ischemic site. Effective in the case of vascular and dystrophic pathology of the fundus. Characteristic is also a tonic effect on the central nervous system, the elimination of functional disorders of the somatic and autonomic nervous systems in alcoholics during the period of abstinence.