Karipazim - instructions for use, doses, side effects, contraindications

Active substancePapaya Milk JuicePapaya Milk Juice

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Caripazim

lyophilizate externally

ATC-PHARMACY, LLC Russia

Caripazim

lyophilizate externally

MEDFLORINA, LLC Russia

Caripazim

lyophilizate externally

VIFITEH, CJSC Russia

Caripazim

lyophilizate externally

Institute of Pharmacochemistry im.GKutateladze Academy of Sciences of Georgia Georgia

Dosage form: & nbsplyophilizate for the preparation of a solution for external use

Composition:

Per 1 bottle:

Papain - 350 PE and 700 PE.

Description:

Lyophilized powder white or white with a slightly yellowish hue.

Pharmacotherapeutic group:Proteolytic agent

ATX: & nbsp

D.03.B Enzyme preparations

Pharmacodynamics:

Proteolytic agent for external use. Enzyme preparation, by the mechanism of action is similar to chymotrypsin and trypsin.

With external application, it breaks necrotic tissues, liquefies a viscous secretion, exudate.

With the experimental study of the use of electrophoresis, the drug affects collagen cartilage tissues, enhances the regeneration of intervertebral disc tissues.

In the clinical application of caripazim by electrophoresis for 14 days against the background of standard therapy, reliable positive dynamics of a number of diagnostic parameters of dorsopathy, a tendency to decrease neuropathological symptoms and an improvement in the quality of life were shown.

Pharmacokinetics:

When applied externally, the drug is not absorbed and does not have systemic effects on the body.

Indications:Burns III-a degree (to accelerate the rejection of the sculls and to cleanse granulating wounds from purulent-necrotic masses).

As an aid in the complex therapy of dorsopathy of various parts of the spine.

Contraindications:

Hypersensitivity to the drug. Pregnancy, lactation.

Dosing and Administration:

With burns IIIdegree.

External, in the form of solutions 35 PE / ml and 70 PE / ml, depending on the thickness of the scab. The content of the vial is diluted in 10 ml of 0.5% solution of procaine or 0.9% solution of sodium chloride. The solution is prepared immediately before use. A tissue moistened with a drug is applied to the burn surface, covered with a waterproof bandage, which is changed once a day or every other day, removing the exfoliated necrotic tissue. At the same time, no more than 30% of the total body surface is treated. The course of treatment is from 4 to 12 days.

External by the method of electophoresis.

The solution is prepared immediately before use.

The content of the vial is diluted in 10 ml of 0.5% solution of procaine or 0.9% solution of sodium chloride.To the resulting solution, 0.02-0.06 mg (2-3 drops) of Dimexide (dimethylsulfoxide) is added. The filter paper is uniformly wetted with the prepared solution, placed on a positive electrodes pad of the electrophoresis apparatus, and placed on the pathology area. On the laying of the negative electrode, water is applied, 3-5 ml of a 2.4% solution of aminophylline or potassium iodide. The temperature of the gaskets should be from 37 ° C to 39 ° C.

Possible options for the location of the gaskets (determined by a physician-physiotherapist):

(+) electrode on the neck area,

(-) electrode on the waist region, longitudinally

(+) electrode on the neck area,

(-) electrode bifurcated on both arms, longitudinally

(+) electrode on the lower back,

(-) electrode bifurcated into both thighs, longitudinally at the exit points of the sciatic nerve

(+) electrode on the waist region,

(-) electrode on the abdomen, transversely

The procedure of electrophoresis is carried out at a current strength of 5 to 15 mA, starting at 5 mA; Exposure time from 10 to 20 minutes with a gradual increase.

The course of treatment is not less than 14 procedures. Repeated courses are conducted after consultation with the doctor after 30-45 days.

Side effects:

Allergic reactions.

Overdose:

Cases of overdose are not described.

Interaction:

Clinically significant interactions with other drugs have not been established.

Form release / dosage:

Liofilizate for the preparation of a solution for external use 350 PE and 700 PE.

Packaging:

By 350 PE and 700 PE in glass bottles, corked with rubber stoppers and crimped with aluminum caps.

Each bottle, together with the instructions for use, is placed in a pack of cardboard.

For 10 or 50 bottles together with the instructions for use are placed in a box of cardboard.

Marking.

Primary packaging

The label of the vial indicates the name of the medicinal product, the dosage form, the activity in the PE in the vial, Series No., is valid before.

Secondary packaging

On the secondary packaging indicate the name of the medicinal product, dosage form, activity in PE in the vial, Serial No., valid before, manufacturer, address, telephone / fax, registration number, method of application, conditions of leave, storage conditions, "Keep out of reach : children's place "," Sterile "," Use as directed by a doctor "," Do not use after expiry date ", bar code, holographic protective element.

The group packaging is additionally indicated by the number of packages.

Storage conditions:

In dry, dark place at a temperature of no higher than 15 ° C.

Keep out of the reach of children.

Shelf life:

1 year 6 months

Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:LSR-002813/09

Date of registration:08.04.2009 / 04.02.2015

Expiration Date:Unlimited

The owner of the registration certificate:MEDFLORINA, LLC MEDFLORINA, LLC Russia

Manufacturer: & nbsp

MEDFLORINA, LLC Russia

Information update date: & nbsp13.12.2017

Illustrated instructions

Instructions

Caripazim (Caripazim)