Included in the formulation
АТХ:R.05.F.A.02 Opium derivatives in combination with expectorants
Pharmacodynamics:The opioid activity of codeine is due to the transformation into morphine. Weak agonist opioidnyh λ- and φ-receptors (activation of λ-receptors is 3 times stronger than φ): suppression of interneuronal transmission of pain impulses in the afferent ways of the central nervous system, a decrease in the emotional evaluation of pain and reaction to it. Pronounced antitussive effect.
Sodium bicarbonate, licorice roots, the thermpsis of the lanceolate grass - oreflex action concealers. ABOUTCauses irritating effect on mucosal receptors stomach, reflexively increase the secretion of the bronchial glands and the mobility of the ciliated epithelium. As a result of an increase in the amount of secretion, sputum becomes more fluid, less viscous and adhesive. Increased activity of ciliated epithelium and peristaltic movements of bronchioles promotes sputum from the lower in the upper respiratory tract and its excretion.
Pharmacokinetics:The components of the drug are well absorbed into the digestive tract.
Codeine slightly binds to plasma proteins. It is subject to biotransformation in the liver (10% by demethylation passes into morphine). It is excreted by the kidneys (5-15% - unchanged).
The pharmacokinetics of licorice and lanceolate thermopsis have not been studied.
Sodium bicarbonate is eliminated by the kidneys formed by CO2 - the lungs.
Indications:Cough of different genesis.
Contraindications:Hypersensitivity, marked renal / hepatic insufficiency, respiratory disorders due to respiratory center depression, asthmatic status, pulmonary insufficiency, pregnancy, lactation period, children's age (up to 2 years).
Carefully:Children under 12 years.
Pregnancy and lactation:The category of FDA recommendations is not defined.
The drug is contraindicated for use in pregnancy and lactation.
Dosing and Administration:Inside 1 tablet 2-3 times a day.
The maximum single dose of codeine is 50 mg. The maximum daily dose of codeine is 200 mg. The recommended duration of therapy is 3 to 5 days. Patients with reduced renal function may need a dose adjustment.
Side effects:From the nervous system and sensory organs: headache, drowsiness.
On the part of the digestive system: nausea, vomiting, constipation.
Others: allergic reactions.
Overdose:Symptoms: agitation, nausea, heaviness in the head, insomnia, hypoglycemia, drowsiness, itching, vomiting, arrhythmia, bradycardia, bradypnoe, nystagmus and atony of the bladder. May accelerate the development of severe respiratory failure.
Treatment: a specific antidote of codeine - naloxone, symptomatic therapy.
Interaction:Do not prescribe concomitantly with other drugs that depress the central nervous system, including hypnotics and sedatives, ethyl alcohol, antihistamines, central analgesics, anxiolytics and antipsychotic drugs. Chloramphenicol potentiates the action of codeine by slowing its metabolism.
High doses of codeine, when combined, increase plasma concentrations of cardiac glycosides.
Astringent, enveloping and enterosorbent agents in combined use reduce the plasma concentrations of its active components.
Special instructions:It is possible to reduce the concentration and speed of psychomotor reactions, therefore, during the treatment period, care should be taken when driving vehicles and engaging in other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.
Can influence the results of doping control.
With prolonged, uncontrolled use, it is possible to develop addiction (weakening analgesic effect) and drug dependence.