From the digestive system: gastralgia, decreased appetite, nausea, vomiting, diarrhea, constipation, flatulence, abdominal pain, increased activity of "liver" transaminases, hyperbilirubinemia, cholestatic jaundice, pseudomembranous colitis, dryness of the oral mucosa, colitis (including hemorrhagic) , hepatitis.
From the nervous system: headache, dizziness, insomnia, nervousness, motion uncertainty, tremor, convulsions, numbness and paresthesia of the extremities, intense dreams, nightmares, anxiety, state of arousal, phobias, depression, confusion, hallucinations, increased intracranial pressure, insomnia, nervousness , drowsiness, epileptic seizures, extrapyramidal disorders, psychotic reactions with suicidal tendencies, sensory or sensory-motor peripheral neuropathy, impaired coordination of motion, temporary loss of consciousness.
From the side of the musculoskeletal system: tendonitis, myalgia, arthralgia,
tendosynovitis, tendon rupture, pain in the limbs, rigidity of muscles, rhabdomyolysis, muscle weakness.
From the sense organs: violation of color perception, diplopia, taste disorders, perversion of taste sensations, impaired sense of smell, hearing and balance.
From the cardiovascular system: tachycardia, increase or decrease in blood pressure, collapse, lengthening interval QT, ventricular arrhythmia, incl. arrhythmia ventricular tachysystolic type "pirouette".
Allergic reactions: skin rash, itching, hives, allergic pneumonitis, allergic nephritis, eosinophilia, fever, angioedema, bronchospasm; erythema multiforme (including Stevens-Johnson syndrome) and toxic epidermal necrolysis (Lyell's syndrome), photosensitivity, vasculitis, anaphylaxis, pruritus external genitalia in women.
From the skin: point hemorrhages (petechiae), bullous hemorrhagic dermatitis, papular rash with a cortex, indicative of vascular lesions (vasculitis).
From the hematopoiesis: leukopenia, agranulocytosis, anemia (including aplastic and hemolytic), thrombocytopenia, pancytopenia.
From the urinary system: acute interstitial nephritis, impaired renal function, hypercreatininemia, increased urea concentration, dysuria, urinary retention, acute renal failure.
Other: dysbacteriosis of the intestine, superinfection, hypoglycemia (in patients with diabetes mellitus), vaginitis, chest pain, fatigue, asthenia, general weakness, photosensitivity, vaginal discharge, epistaxis, thirst, weight loss, pharyngitis, rhinitis, dry cough, acute attack porphyria (in patients with porphyria).