Koblipen (Combilipen)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspsolution for intramuscular injection
Composition:

Active substances:

Thiamine hydrochloride

100 mg

Pyridoxine hydrochloride

100 mg

Cyanocobalamin

1.0 mg

Lidocaine hydrochloride

20 mg

Auxiliary substances: benzyl alcohol 40 mg, sodium tripolyphosphate 20 mg, potassium hexacyanoferrate 0.2 mg, sodium hydroxide to pH 4.5 ± 0.2, water for injection up to 2 ml.

Description:Transparent pinkish-red liquid with a specific smell.
Pharmacotherapeutic group:multivitamin
ATX: & nbsp
  • Other drugs for the treatment of diseases of the nervous system
    • Pharmacodynamics:

    Combined multivitamin preparation. The effect of the drug is determined by the properties of the vitamins that make up its composition. Neurotropic B vitamins have a beneficial effect on inflammatory and degenerative diseases of the nervous system and motor apparatus.

    Thiamine hydrochloride (vitamin B1) - involved in the conduct of a nerve impulse.

    Pyridoxine hydrochloride (vitamin B6) - has a vital effect on the exchange of proteins, carbohydrates and fats, is necessary for normal hematopoiesis, the functioning of the central and peripheral nervous system. Provides a synaptic reintroductiondacha, braking processes in the central nervous system, participates in the transpoppmwithfingosin, which is part of the nerve shell, is involved in the synthesis of catecholamines.

    Cyanocobalamin (vitamin B12) - involved in the synthesis of nucleotides, is an important factor in normal growth, hematopoiesis and the development of epithelial cells; is necessary for the metabolism of folic acid and myelin synthesis.

    Lidocaine has an anesthetic effect at the injection site, dilates the blood vessels, contributing to the absorption of vitamins. The local anesthetic effect of lidocaine is due to the blockade of potential-dependent Na + -channels, which prevents the generation of pulses in the endings of the sensory nerves and pain impulses along nerve fibers.

    Indications:

    In the complex therapy of the following diseases:

    - polyneuropathy, including diabetic and alcoholic;

    - neuritis and neuralgia: neuralgia of the trigeminal nerve, neuritis of the facial nerve, intercostal neuralgia;

    - pain syndrome caused by diseases of the spine (dorsalgia, lumboschialgia, plexopathy, radicular syndrome caused by degenerative changes in the spine).

    Contraindications:

    Hypersensitivity to the components of the drug, severe and acute forms of decompensated heart failure,pregnancy and lactation period, children's age, due to lack of data.

    Pregnancy and lactation:

    The use of the drug is not recommended.

    Dosing and Administration:

    In cases of severe pain, it is advisable to start treatment with intramuscular injection (deep) 2 ml daily for 5-10 days with a transition in the future either for oral administration or for rarer injections (2-3 times a week for 2-3 weeks) with possible continuation of therapy with the oral dosage form.

    Weekly monitoring of therapy by a physician is necessary.

    Side effects:

    The incidence of adverse adverse reactions is given in accordance with the WHO classification:

    Often

    more than 1 in 10 treated

    Often

    less than 1 in 10, for more than 1 in 100 treated

    Infrequently

    less than 1 in 100, for more than 1 in 1,000 treated

    Rarely

    less than 1 in 1000, but more than 1 in 10,000 undergoing treatment

    Rarely

    less than 1 in 10,000, including individual cases

    Frequency unknown

    It is impossible to estimate on the basis of available data

    From the immune system:

    rarely: allergic reactions (skin rash, shortness of breath, anaphylactic shock, Quincke's edema);

    From the nervous system:

    frequency is unknown: dizziness, confusion of consciousness;

    From the cardiovascular system:

    rarely: tachycardia;

    Co hand gastrointestinal tract:

    frequency is unknown: vomiting;

    From the skin and subcutaneous tissues:

    rarely: increased sweating, acne, pruritus, urticaria;

    From the side of musculoskeletal and connective tissue:

    frequency is unknown: convulsions;

    General disorders and disorders at the site of administration:

    frequency is unknown: irritation may occur at the injection site; Systemic reactions are possible with rapid administration or overdose.

    If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

    With the rapid introduction (e.g., due to inadvertent intravascular injection or injection into the tissue with a rich blood supply) or at excess dose may develop systemic reactions, including confusion, vomiting, bradycardia, arrhythmia, dizziness and cramps.

    Overdose:

    Symptoms: dizziness, nausea, vomiting, itching, urticaria; increased sweating, tachycardia.

    Treatment: symptomatic.

    Interaction:

    Vitmain B1 completely disintegrates in solutions containing sulfites. And, as a consequence, the products of thiamine decomposition inactivate the actions of other vitamins.

    Thiamin is incompatible with oxidizing and reducing compounds, including mercury chloride, iodide, carbonate, acetate, tannic acid, iron ammonium citrate, as well as sodium phenobarbital, riboflavin, benzyl penicillin, dextrose and metabisulphite.

    Copper accelerates the destruction of thiamine; Besides, thiamine Loses its effectiveness with increasing pH (more than 3).

    Therapeutic doses of vitamin B6 (pyridoxine) weaken the effect of levodopa (the antiparkinsonian effect of levodopa is reduced) with simultaneous admission. There is also interaction with cycloserine, penicillamine, isoniazid.

    Vitamin B12 (cyanocobalamin) is incompatible with salts of heavy metals.

    Riboflavin also has a destructive effect, especially when exposed to light; nicotinamide accelerates photolysis, while antioxidants have an inhibitory effect.

    When parenteral application of lidocaine in the case of additional use of norepinephrine and epinephrine is possibleincreased side effects on the heart. Interactions with sulfonamides are also observed.

    Effect on the ability to drive transp. cf. and fur:

    Information about caution regarding the use of the drug by drivers of vehicles and persons working with potentially dangerous mechanisms is not available.

    Form release / dosage:

    Solution for intramuscular injection.

    Packaging:

    2 ml per ampoule of light-protective glass.

    5 ampoules per contour cell packaging made of polyvinyl chloride film.

    1 or 2 contour packs together with the instruction but are placed in a pack of imported cardboard.

    Storage conditions:

    In the dark place at a temperature of 2 ° C to 8 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after expiry date.

    Terms of leave from pharmacies:On prescription
    Registration number:LS-001680
    Date of registration:02.08.2010
    The owner of the registration certificate:PHARMSTANDART-UFIM VITAMIN FACTORY, OJSC PHARMSTANDART-UFIM VITAMIN FACTORY, OJSC Russia
    Manufacturer: & nbsp
    Representation: & nbspPHARMSTANDART-Ufa-VITA, JSCPHARMSTANDART-Ufa-VITA, JSC
    Information update date: & nbsp24.09.2015
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