Levomethyl (Levometil)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceDioxomethyltetrahydropyrimidine + ChloramphenicolDioxomethyltetrahydropyrimidine + Chloramphenicol
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  • Levomekol®
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  • Levomethyl
    ointment externally 
    GREEN DUBRAVA, CJSC     Russia
  • Levomicon-TFF
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    TULA PHARMACEUTICAL FACTORY, LTD.     Russia
    • Dosage form: & nbspointment for external use
    Composition:

    Per 100 g:

    Active substances: chloramphenicol (levomycetin) 0.75 g, dioxomethyltetrahydropyrimidine (methyluracil) 4.0 g;

    Excipients: Macrogol 400 (polyethylene oxide 400) - 76.2 g, macrogol 1500 (polyethylene oxide 1500) - 19.05 g.

    Description:Ointment is white or white with a yellowish hue.
    Pharmacotherapeutic group:Antimicrobial medication combined
    ATX: & nbsp

    D.06.C   Antibiotics in combination with other antimicrobials

    Pharmacodynamics:Combined drug for external use, has anti-inflammatory (dehydrating) and antimicrobial effect. Chloramphenicol violates the process of protein synthesis in a microbial cell and refers to antibiotics of bacteriostatic action. It is active against gram-positive and gram-negative microorganisms (staphylococci, Pseudomonas aeruginosa and Escherichia coli, etc.).Easily penetrates into the tissues without damaging the biological membranes. In the presence of pus and necrotic masses, antibacterial action persists. Dioxomethyltetrahydropyrimidine, normalizing the nucleic acid metabolism, stimulates the regeneration processes in the wounds, growth and granulation maturation of the tissue, epithelization, has an anti-inflammatory (dehydrating) effect.
    Pharmacokinetics:

    The drug is absorbed insignificantly and systemically action has no effect.

    Indications:Purulent wounds (including those infected with mixed microflora) in the first (purulent-necrotic) phase of the wound process.
    Contraindications:

    Hypersensitivity, skin mycosis, dermatitis, eczema, psoriasis.

    Carefully:Pregnancy, lactation, children under 1 year.
    Pregnancy and lactation:

    Applicable only if the intended benefit to the mother exceeds the potential risk to the fetus and the baby.

    Dosing and Administration:

    Outwardly. A strip of ointment with a diameter of 5 mm and a length of 1 cm has an average weight of 0.3 g, which corresponds to 10 mg of chloramphenicol and 20 mg of dioxomethyltetrahydropyrimidine. For adults and children, the drug is applied once a day directly to the damaged areas of the skin at a rate of 0.3 g per cm2 wound surface or applied to sterile gauze wipes at the rate of 0.3-0.6 g per 1 cm2 wound surface, cover the damaged area of ​​the skin with a napkin and fix it with a bandage. Deep wounds loosely filled with sterile gauze napkins, impregnated with the drug. In the purulent cavity the drug is injected with a syringe through a catheter or drain tube, pre-heating the ointment to 35-36 ° C. Dressings are carried out daily, once a day, until complete cleansing wounds from purulent-necrotic masses. The daily dose of ointment in terms of chloramphenicol not should exceed 3 g of chloramphenicol.

    The course of treatment is from 5 to 14 days, depending on the severity and course of the disease.

    Side effects:

    Allergic reactions (urticaria, angioedema). In this case, the drug is discontinued and antihistamines are prescribed.

    Overdose:

    It is unlikely in connection with low absorption. When applying the ointment on extensive surfaces and long-term treatment, there may be symptoms on the part of the hematopoietic system - anemia, leukopenia, thrombocytopenia, reticulocytopenia, which usually occur after withdrawal of the drug and the appointment of symptomatic therapy.

    Interaction:

    When simultaneous application with external medicinal forms of erythromycin, clindamycin, lincomycin and gentamicin, mutual weakening of action.

    Special instructions:

    When applied to large areas of the skin and prolonged courses of treatment, it is necessary to conduct a clinical blood test.

    Effect on the ability to drive transp. cf. and fur:The drug does not affect the ability to engage in potentially hazardous activities requiring special attention and quick reactions (driving and other vehicles, working with moving mechanisms, dispatcher and operator work, etc.).
    Form release / dosage:

    Ointment for external use application.

    Packaging:

    In aluminum tubes of 30.0 g, 40 g. Each tube, together with instructions for medical use, is placed in a pack of cardboard. For 0.1 kg; 0,5 kg; 1.0 kg; 1.5 kg; 2.0 kg; 2.5 kg; 3.0 kg; 5.0 kg; 10.0 kg or 20.0 kg in polymer cans with a lid (for treatment and prophylactic institutions).

    Storage conditions:

    In dry, dark place at a temperature of 12 - 15 ° C.

    Keep out of the reach of children.

    Shelf life:3 years 6 months. Do not use after the expiration date.
    Terms of leave from pharmacies:For hospitals
    Registration number:P N003800 / 01
    Date of registration:02.12.2009 / 10.04.2017
    Expiration Date:Unlimited
    The owner of the registration certificate:GREEN DUBRAVA, CJSC GREEN DUBRAVA, CJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp11.03.2018
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