Dioxomethyltetrahydropyrimidine - instructions for use, dose, side effects, contraindications

Pharmacodynamics:Immunostimulating agent. Promotes the normalization of the exchange of nucleic acids, accelerates the processes of cellular regeneration in wounds,accelerates the growth and maturation of the granulation tissue and epithelialization (including bystroproliferiruyuschih mucosal blood cells), stimulates erythro- and leucopoiesis, cellular and humoral immunity factors. Has anabolic activity, anti-inflammatory effect. With external application also has a photoprotective effect.

Pharmacokinetics:Easily penetrates the skin. The half-life is 5.5 hours. C_max of active substances in the blood is achieved 3-4 hours after application and is maintained for 12 hours.

Indications:

For oral administration: leukopenia (light form, including arose as a result of chemotherapy of malignant tumors, with X-ray and radiation therapy), neutropenic angina, septic angina, anemia, thrombocytopenia, benzene poisoning, radiation damage, convalescence (after severe infections), peptic ulcer gastric and duodenal ulcer (in combination therapy), vyalozazhivayuschie wounds, burns, fractures, hepatitis, pancreatitis.

Locally: vyalozazhivayuschie wounds, burns, fractures, fotodermatit, trophic ulcers, pressure ulcers, deep wounds.

Rectal: rectine, sigmoiditis, ulcerative colitis.

ICD-10

III.D60-D64.D64.9 Anemia, unspecified

III.D70-D77.D70 Agranulocytosis

III.D65-D69.D69.6 Thrombocytopenia, unspecified

XI.K20-K31.K26 Duodenal ulcer

XI.K20-K31.K25.4 Stomach ulcer chronic or unspecified with bleeding

XI.K20-K31.K25 Stomach ulcer

XI.K70-K77.K76.9 Liver disease, unspecified

Contraindications:Hypersensitivity, for ingestion - leukemia (leukemia, especially myeloid), lymphogranulomatosis, hemoblastosis, malignant neoplasms of the bone marrow; locally - redundancy of granulations in the wound; rectally - children's age till 8 years.

Carefully:Children's age, lymphogranulomatosis.

Pregnancy and lactation:The drug is contraindicated for use in pregnant women and during lactation.

Dosing and Administration:

Inside, topically, rectally.

Inside: during or after meals - 0.5 g 4 times a day (if necessary up to 6 times a day); children of 3-8 years - 0.25 g, over 8 years - 0.25-0.5 g 3 times a day. Course with diseases of the digestive tract - 30-40 days; in other cases it may be shorter.

Locally: ointment is applied a thin layer on the affected skin 1-2 times a day. The sponge is applied to the wound surface so that it fits snugly to the bottom and walls of the wound, and the edges extend beyond the wound by 1-1.5 cm, and a bandage is applied from above.Preliminarily, the wound should be treated with an antiseptic solution and the remains of necrotic tissue removed. The frequency of bandages depends on the depth and area of the wound surface, the intensity of exudation and the presence of necrotic masses. On the average, the dressing is recommended to be done once in 2-3 days, since during this period the sponge is completely lysed. If the sponge did not resolve and there are no indications for bandaging (pain, burning sensation in the wound area, accumulation of purulent exudate, the presence of allergic reactions), it is not removed until the wound is completely healed or filled with granulation tissue to the full depth.

Rectal: adults - 0.5-1 g (1-2 suppositories) 3-4 times a day; children of 8-15 years - 500 mg per day.

Side effects:Possible: allergic reactions; when ingested - headache, dizziness, heartburn.

Overdose:There is no evidence of an overdose of the drug. In case of an overdose, symptomatic therapy should be given.

Interaction:Clinically significant interactions were not detected. Do not apply topically at the same time as other products.

Special instructions:The drug should be used strictly according to the appropriate indications.

Instructions

Dioxomethyltetrahydropyrimidine (Dioxomethyltetrahydropyrimidinum)