From the gastrointestinal tract: nausea, vomiting, diarrhea, lack of appetite, unpleasant metallic taste in the mouth, epigastric pain. Violation of the function of the liver.
From the central nervous system: with prolonged use of headache, dizziness, increased excitability, depression, sleep disturbance, weakness; in some cases - confusion, hallucinations, convulsions;
On the part of the organs of hematopoiesis and the system of hemostasis: thrombocytopenia, sideroblastic anemia, erythrocyte vacuolization, porphyria, hypercoagulation, splenomegaly;
From the side of the musculoskeletal system: myalgia;
From the urinary system: dysuria, interstitial nephritis;
Other: hyperthermia, acne, increased serum iron concentration.
Possible allergic reactions, arthralgia, hyperuricemia, exacerbation of gout, photosensitivity.There is evidence of a delay in the body under the influence of pyrazinamide, uric acid, and possibly the appearance of arthritic pain in the joints. Therefore, it is advisable to monitor the activity of hepatic transaminases and the content of uric acid in the blood regularly (at least once a month).
Possible development of hypoglycemia in patients with diabetes mellitus.
With prolonged use may have toxic effects on the liver.