Active substancePyrazinamidePyrazinamide Similar drugsTo uncover Linamide pills inwards FARMGID CJSC Russia Macroside® pills inwards McLeodz Pharmaceuticals Co., Ltd. India Pisina pills inwards Lupine Co., Ltd. India Pyrazinamide pills inwards VALENTA PHARM, PAO Russia Pyrazinamide pills inwards FORTYUN MED, LTD Russia Pyrazinamide pills inwards ROSFARM, LLC Russia Pyrazinamide pills inwards OZONE, LLC Russia Pyrazinamide pills inwards NORTH STAR, CJSC Russia Pyrazinamide pills inwards FARMSINTEZ, PAO Russia Pyrazinamide STADA pills inwards NIZHFARM, JSC Russia Pyrazinamide-Acry® pills inwards AKRIKHIN HFK, JSC Russia Pyrazinamide-NIKA pills inwards NIKK, CJSC Russia Pirafat pills inwards Rimzer Artsynaimitel, AG Germany Dosage form: & nbspPills. Composition:One tablet contains:active substance: pyrazinamide 250 mg and 500 mg;Excipients: potato starch, calcium stearate, croscarmellose sodium. Description:The tablets are white, round, flat with a facet and separation risk on one side. Pharmacotherapeutic group:Anti-tuberculosis drug. ATX: & nbspJ.04.A.K.01 Pyrazinamide Pharmacodynamics:Pyrazinamide - antituberculous drug. It acts on intracellularly located mycobacteria, it penetrates well into the centers of tuberculous lesion. More effective in an acidic environment.Has a bacteriostatic or bactericidal effect depending on the concentration and sensitivity of the microorganism.In the course of treatment, the development of resistance is possible, the probability of which decreases when combined with other antituberculous drugs. Pharmacokinetics:Pyrazinamide well absorbed from the gastrointestinal tract. Pyrazinamide well penetrates into the tissues and body fluids, including the liver, lungs, cerebral fluid. The connection with plasma proteins is 10-20%. Time to reach the maximum concentration - 1-2 hours.Metabolised in the liver, where an active metabolite, pyrazinic acid, is first formed, which is then converted into an inactive metabolite, 5-hydroxypyrazinic acid.It is excreted by the kidneys: in unmodified form - 3%, in the form of pyrazinic acid - 33%, in the form of other metabolites - 36%. The half-life is 8-9 hours. Indications:In combination with other anti-tuberculosis drugs are prescribed in the following cases: pulmonary tuberculosis, tuberculosis meningitis, tuberculosis of bones, tuberculosis of urogenital organs. Contraindications:Hypersensitivity, children under 3 years. Carefully:Hyperuricemia, gout, hepatic insufficiency. Dosing and Administration:The drug is used inside with food or after eating, once a day, preferably at breakfast, with a little water. Adults prescribe 25-30 mg / kg (with a body weight of less than 50 kg - 1.5 g, more than 50 kg - 2 g) per day. The maximum daily dose is 2.5 g. The course of treatment is 3 months.In case of unsatisfactory portability Pyrazinamide appoint 2-3 reception.In elderly and senile patients, the daily dose should not exceed 15 mg / kg. In these cases, the drug should be administered every other day.Children from 3 years are prescribed 15-20 mg / kg once a day, the maximum daily dose is 1.5 g. Pyrazinamide used in combination with aminoglycosides (streptomycin or kanamycin in a dose of 15 mg / kg), isoniazid (10 mg / kg), rifampicin (10 mg / kg). Side effects:From the digestive system: nausea, vomiting, diarrhea, "metallic" taste in the mouth, epigastric pain, impaired liver function (decreased appetite, liver tenderness, hepatomegaly, jaundice, yellow atrophy of the liver), exacerbation of peptic ulcer.From the central nervous system (CNS): headache, dizziness, increased excitability, depression, sleep disturbance; in some cases - hallucinations, convulsions, confusion.On the part of the organs of hematopoiesis and the system of hemostasis: thrombocytopenia, sideroblastic anemia, erythrocyte vacuolization, porphyria, hypercoagulation, splenomegaly.From the musculoskeletal system: arthralgia, myalgia.From the urinary system: dysuria, interstitial nephritis.Allergic reactions: skin rash, hives.Other: hyperthermia, acne, hyperuricemia, exacerbation of gout, photosensitivity, increased serum iron concentration. Overdose:Symptoms: a violation of liver function, an increase in the severity of side effects from the central nervous system.Treatment: symptomatic. Interaction:Pyrazinamide compatible with other antituberculous drugs: in chronic destructive forms it is recommended to combine it with rifampicin or ethambutol (better tolerability than when combined with rifampicin, but weaker effect).The likelihood of developing a hepatotoxic effect of the drug is increased when combined with rifampicin.When used simultaneously with drugs that block tubular secretion (probenecid), it is possible to reduce their excretion and enhance toxic reactions. Special instructions:With long-term treatment, it is necessary to monitor the activity of hepatic transaminases and the content of uric acid in the blood once a month.In patients with diabetes, the risk of hypoglycemia increases. Form release / dosage:Tablets 250 mg and 500 mg. Packaging:For 100 tablets in a jar of polypropylene or low-density polyethylene. Each jar along with instructions for use in a pack of cardboard. Storage conditions:List B. Store in a dry, the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children. Shelf life:3 years. The drug should not be used after the expiration date. Terms of leave from pharmacies:On prescription Registration number:LSR-004058/09 Date of registration:25.05.2009 The owner of the registration certificate:ROSFARM, LLC ROSFARM, LLC Russia Manufacturer: & nbspROSFARM, LLC Russia Information update date: & nbsp30.07.2015 Illustrated instructions × Illustrated instructions Instructions