Classification of the incidence of side effects according to the recommendations of the World Health Organization (WHO): very often> 1/10; often from> 1/100 to <1/10; infrequently from> 1/1000 to <1/100; rarely from> 1/10000 to <1/1000; very rarely <1/10000, including individual messages; the frequency is unknown - it is not possible to establish the frequency of occurrence from the available data.
From the central nervous system:
often - headache, dizziness, drowsiness, imbalance;
infrequent - gait disturbance, confusion, hallucinations (hallucinations were observed, mainly, in patients with dementia of the Alzheimer's type of severe degree);
very rarely - convulsions;
frequency unknown - psychotic reactions, impaired consciousness, increased excitability, depression, anxiety, suicidal thoughts, increased intracranial pressure, muscle hypertonia.
From the side of the cardiovascular system:
often - increased blood pressure;
infrequently - venous thrombosis / thromboembolism, heart failure.
From the digestive system:
often constipation;
infrequently - nausea, vomiting;
frequency unknown - pancreatitis, hepatitis.
From the respiratory system:
often - shortness of breath.
From the genitourinary system:
frequency unknown - acute renal failure, cystitis, increased libido.
Allergic reactions:
often - hypersensitivity to the components of the drug;
frequency is unknown - allergic reactions, Stevens-Johnson syndrome.
From the skin:
frequency unknown - thrombocytopenic purpura.
Laboratory indicators:
often - increased activity of "liver" enzymes;
frequency unknown - agranulocytosis, leukopenia (including neutropenia), pancytopenia, thrombocytopenia.
Other:
infrequently - increased fatigue;
rarely fungal infections; frequency unknown - candidiasis.