Below are presented the undesirable reactions, obtained both during the conducted researches, and from spontaneous reports.
WHO classification of the incidence of adverse reactions: very often (≥1 / 10); often (≥1 / 100, <1/10); infrequently (≥1 / 1000, <1/100); rarely (≥1 / 10000, <1/1000); very rarely (<1/10000), the frequency is unknown - it is not possible to establish the frequency of occurrence according to the available data.
Infectious and parasitic diseases
Infrequently: fungal infections.
Frequency unknown: Candidiasis.
Immune system disorders
Often: hypersensitivity to the components of the drug.
The frequency is unknown: allergic reactions, Stevens-Johnson syndrome.
Disorders from the psyche
Infrequently: hallucinations (observed mainly in patients with severe Alzheimer's disease).
The frequency is unknown: psychotic reactions, increased excitability, depression, anxiety, suicidal thoughts.
Disturbances from the nervous system
Often: headache, dizziness, drowsiness, imbalance. Infrequent: gait disturbance, confusion.
Very rarely: convulsions.
The frequency is unknown: impaired consciousness, increased intracranial pressure, muscle hypertonia.
Heart Disease
Infrequent: heart failure.
Vascular disorders
Often: increased blood pressure.
Infrequent: venous thrombosis and / or thromboembolism.
Disturbances from the respiratory system, chest and mediastinal organs
Often: shortness of breath.
Disorders from the gastrointestinal tract
Often: constipation.
Infrequent: nausea, vomiting.
Frequency unknown: pancreatitis.
Disorders from the liver and bile ducts:
Frequency unknown: hepatitis.
Disturbances from the skin and subcutaneous tissues
Frequency unknown: thrombocytopenic purpura.
Disorders from the genitourinary system
The frequency is not known: acute renal failure, cystitis, increased libido.
General disorders
Infrequent: fatigue, general weakness.
Laboratory and instrumental data:
Often: increased activity of "liver" enzymes.
The frequency is unknown: agranulocytosis, leukopenia (including neutropenia), pancytopenia, thrombocytopenia.