Symptoms
Dizziness, tremor, agitation, drowsiness, confusion, agitation, stupor, convulsions, psychosis, aggressiveness, hallucinations, gait unsteadiness, vomiting, diarrhea.
Treatment
There is no specific antidote. In case of overdose, symptomatic therapy and measures aimed at accelerated removal of the drug from the body (gastric lavage, activated charcoal intake, urine acidification, forced diuresis) are performed.
Clinical experience
Relatively large doses of the drug (200 mg and 105 mg / day for 3 days, respectively) caused symptoms of fatigue, weakness, diarrhea, some patients had no overdose symptoms.
After an overdose of the drug in a dose of 140 mg (the exact dose is unknown), the patient developed symptoms from the CNS, including confusion, drowsiness, dizziness, agitation, increased aggression, hallucinations and gait disturbance, and gastrointestinal symptoms (vomiting and diarrhea) .
After taking 400 mg memantine, there was a marked symptom from the CNS (anxiety, psychosis, visual hallucinations, convulsive alertness, drowsiness, stupor and loss of consciousness). The patient survived and recovered without any consequences.
After taking 2000 mg of memantine, the development of a coma (10 days) was observed, followed by the development of diplopia and agitation. The patient underwent symptomatic therapy, plasmapheresis. Symptoms of overdose resolved without the development of persistent complications.