Classification of the WHO frequency of development of adverse reactions: very often -≥1/10 appointments (> 10%)
often from ≥1 / 100 to <1/10 of appointments (> 1% and <10%)
infrequently - from ≥1 / 1000 to <1/100 of prescriptions (> 0.1% and <1%)
rarely - from ≥1 / 10,000 to <1/1000 appointments (> 0.01% and <0.1%) very rarely - <1/10000 prescriptions (<0.01%)
the frequency is unknown - it is not possible to establish the frequency of occurrence from the available data.
Infectious and parasitic diseases
Infrequently: fungal infections.
Immune system disorders
Often: hypersensitivity to the components of the drug.
Disorders of the psyche
Infrequent: confusion, hallucinations (observed mainly in patients with severe Alzheimer's disease).
The frequency is not known: psychotic reactions.
Disturbances from the nervous system
Often: headache, dizziness, drowsiness, imbalance.
Infrequent: a violation of gait.
Very rarely: seizures, epileptic seizures.
Heart Disease
Infrequent: heart failure, heart defects.
Vascular disorders
Often: increased blood pressure.
Infrequent: venous thrombosis and / or thromboembolism.
Disturbances from the respiratory system, chest and mediastinal organs
Often: shortness of breath.
Disorders from the gastrointestinal tract
Often: constipation.
Infrequent: nausea, vomiting.
The frequency is not known: pancreatitis.
Disturbances from the liver and bile ducts
Often: impaired functional liver tests.
The frequency is not known: hepatitis.
Violation by the organs of hematopoiesis
The frequency of ns is known: agranulocytosis, leukopenia (including neutropenia), pancytopenia, thrombocytopenia, tromocytopenic purpura.
Violation of the kidneys and urinary tract
The frequency is not known: acute renal failure.
Disturbance of the skin and subcutaneous tissues
The frequency is not known: Stevens-Johnson syndrome.
General disorders and disorders at the site of administration
Infrequent: fatigue, general weakness.
In Alzheimer's disease, depression, suicidal thoughts and suicide cases were recorded in post-marketing studies.