Metronidazole + Chlorhexidine (Metronidazolum + Chlorhexidinum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
Read on
Clinical and pharmacological group: & nbsp

Other synthetic antibacterial agents

Dental tools

Included in the formulation
  • Metrogex®
    gel locally 
    Dr. Reddy's Laboratories Ltd.     India
  • Metrogil Denta®
    gel locally 
    Johnson & Johnson, LLC     Russia
  • Metrodent
    gel locally 
    Metigrins, Open Company     Latvia
    • АТХ:

    A.01.A.B   Antimicrobials for topical use in diseases of the oral cavity

    A.01.A.B.11   Other

    Pharmacodynamics:

    Metronidazole

    The nitro-5-imidazole derivative has an antibacterial and antiprotozoal effect. It recovers 5-nitro group due to transport proteins of anaerobic bacteria and protozoan microorganisms. The restored 5-nitro group of metronidazole inhibits the synthesis of nucleic acids from the DNA of microorganism cells, which leads to their death.

    Active with respect to Gardnerella vaginalis, Giardia lamblia, Entamoeba histolytica, Trichomonas vaginalis, as well as in relation to obligate anaerobes Bacteroides spp. (at t.h. B. distasonis, B. ovatus, B. fragilis, B. vulgatus, B. thetaiotaomicron), Fusobacterium spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens), Veillonella spp., and some gram-positive microorganisms (Clostridium spp., Eubacterium spp., Peptococcus spp., Peptostreptococcus spp.).

    With a mixed flora, it acts synergistically with antibiotics against aerobic bacteria.

    Chlorhexidine

    Antiseptic antimicrobial preparation, is active against gram-positive and gram-negative anaerobic and aerobic bacteria: Bacteroides fragilis, Chlamydia spp., Treponema spp., Neisseria gonorrhoeae, Trichomonas spp., Ureaplasma spp.

    Pharmacokinetics:

    With topical application, the drug does not have a systemic effect.

    Indications:

    It is used for the treatment of acute and chronic gingivitis, periodontitis, parodontosis, aphthous stomatitis, postextraction alveolitis, inflammation of the oral mucosa with the use of prostheses, cheilitis, ulcerative necrotic gingivitis of Vincent.

    ICD-10

    I.A65-A69.A69.1   Other infections of Vincent

    XI.K00-K14.K05   Gingivitis and periodontal disease

    XI.K00-K14.K04.0   Pulpitis

    XI.K00-K14.K12   Stomatitis and related lesions

    XIX.T80-T88.T85.7   Infection and inflammatory response due to other internal prosthetic devices, implants and transplants

    Contraindications:

    Individual intolerance of metronidazole, chlorhexidine.

    Carefully:

    Accidental or deliberate ingestion of a large amount of gel may cause side effects to increase.

    Pregnancy and lactation:

    Recommendations for FDA - category is not defined. A drug does not render systemic action, is used during pregnancy and lactation.

    Dosing and Administration:

    Using a toothbrush, the gel is applied to the gums and interdental spaces 2 times a day. The course of treatment: 7-10 days.

    Side effects:

    Allergic reactions.

    Overdose:

    Not described.

    Interaction:

    Clinically significant interactions were not observed.

    Special instructions:

    Before applying the drug, you need to brush your teeth, rinse your mouth and rub the surface of the gums with a cotton ball. After applying the gel, you must refrain from eating food and drinks for 30 minutes.

    Instructions
    Up