Sodium acetate + Sodium chloride (Natrii acetas + Natrii chloridum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
Read on
Clinical and pharmacological group: & nbsp

Regulators of water-electrolyte balance and KHS

Included in the formulation
  • Disol
    solution in / in 
    ESKOM NPK, OAO     Russia
  • Disol
    solution in / in 
    RESTER, CJSC     Russia
  • Disol
    solution in / in 
    BIOSINTEZ, PAO     Russia
  • Disol
    solution in / in 
    MOSFARM, LLC    
  • Disol
    solution in / in 
    GROTEKS, LLC     Russia
  • Disol
    solution in / in 
    NESVIZH FACTORY OF MEDICAL PREPARATIONS, RUP     Republic of Belarus
  • Disol
    solution in / in 
    Kursk Biofactory - BIOK, FKP     Russia
  • Disol
    solution in / in 
    DALHIMFARM, OJSC     Russia
  • Disol
    solution in / in 
    KRASFARMA, JSC     Russia
  • Disol
    solution in / in 
    BIOCHEMIST, OJSC     Russia
    • Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):

    VED

    АТХ:

    B.05.B.B.01   Electrolytes

    Pharmacodynamics:

    Compensation of sodium salts, chloride ions and acetate ions. Pharmacological effects: rehydrating, plasma-substituting, normalization of water-electrolyte composition of blood and acid-base state, detoxification, diuretic.

    Pharmacokinetics:

    Not studied. Excretion is carried out by the kidneys, a small amount is excreted with sweat.

    Indications:

    Rehydration, hyperkalemia, intoxication on the background of dehydration (cholera, acute dysentery, food toxicoinfection).

    ICD-10

    XIX.T80-T88.T88.2   Shock caused by anesthesia

    XIX.T80-T88.T81.1   Shock during or after the procedure, not elsewhere classified

    XIX.T79.T79.4   Traumatic shock

    XIX.T66-T78.T78.2   Anaphylactic shock, unspecified

    XVIII.R50-R69.R57.9   Shock, unspecified

    XVIII.R50-R69.R57.8   Other types of shock

    XVIII.R50-R69.R57.1   Hypovolemic shock

    XVIII.R50-R69.R57.0   Cardiogenic shock

    XVIII.R50-R69.R57   Shock, not elsewhere classified

    XV.O00-O08.O08.3   Shock caused by abortion, ectopic and molar pregnancy

    I.A30-A49.A48.3   Toxic shock syndrome

    I.A00-A09.A00.9   Cholera, unspecified

    I.A00-A09.A00.1   Cholera caused by vibrio 01, biovar eltor

    I.A00-A09.A00.0   Cholera caused by vibrio 01, biovar cholerae

    I.A00-A09.A00   Cholera

    Contraindications:

    Hypersensitivity, renal, heart failure.

    Carefully:

    Children under 18 years. Elderly age, pregnancy, breast-feeding.

    Pregnancy and lactation:

    The category of FDA recommendations is not defined.

    Qualitative and well-controlled studies on humans and animals have not been conducted. Complications are not registered. There is no information on the penetration into breast milk. Complications are not registered.

    Dosing and Administration:

    Intravenously (struino and drip), under the control of laboratory indicators. The ratio of the injected liquid and diuresis is determined every 6 hours. Within 1 hour, the solution is administered in an amount corresponding to 7-10% of the body weight of the patient; then the jet infusion is replaced by a dropwise addition, for 24-48 hours, at a rate of 40-120 cap / min.Before administration, the solution is warmed to 36-38 ° C. The solution is administered in amounts necessary to restore the volume of fluid lost with feces, vomit, urine and sweat.

    In severe forms of diseases (hypovolemic infectious-toxic shock, decompensated metabolic acidosis, anuria) begin with a jet injection of the drug followed by a transition to a drop.

    With lighter forms of diseases (intoxication and dehydration of the body, metabolic acidosis, oliguria), it can be limited to drip administration of the drug.

    Side effects:

    Edema, tachycardia. In some cases, chills may occur.

    Overdose:

    Possible symptoms (by analogy with other solutions of electrolytes): edema of the papilla of the optic nerve, cerebral edema, convulsions, hyperthermia. The toxic dose of sodium chloride is 100-150 g.

    Treatment of sodium chloride overdose: symptomatic maintenance therapy, hemodialysis.

    Interaction:

    Non-steroidal anti-inflammatory drugs, androgens, estrogens, anabolic hormones, corticotropin, mineralocorticoids, vasodilators or ganglion blockers cause an increase in the retention of sodium ions.

    Special instructions:

    Therapy is carried out under the control of hematocrit and the concentration of blood electrolytes.

    Instructions
    Up