Sodium thiosulfate (Sodium thiosulfate)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceSodium thiosulfateSodium thiosulfate
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    • Dosage form: & nbspsolution for intravenous administration
    Composition:

    Active substance:

    Sodium thiosulfate -300 mg Excipients:

    Sodium bicarbonate - 20 mg Water for Injection - up to 1 ml
    Description:clear colorless liquid
    Pharmacotherapeutic group:complexing agent
    ATX: & nbsp

    V.03.A.B   Antidotes

    Pharmacodynamics:

    Complexing agent.

    Has detoxification, anti-inflammatory, desensitizing effect, neutralizes preparations of halides (iodine). When the compounds are poisoned with arsenic, mercury, lead forms non-poisonous sulfites. When poisoned with cyanides, it forms less toxic rhodanous compounds. In an acidic environment decomposes to form sulfur and sulfurous anhydride, which have an antiparasitic effect.

    Pharmacokinetics:

    After an induction, it spreads in the extracellular fluid.

    It is excreted from the body with urine. The half-life is 0.65 hours.

    Indications:

    When the compounds are poisoned with arsenic, mercury, lead (non-toxic sulfites are formed), hydrocyanic acid and its salts (less poisonous rhodanous compounds are formed), iodine salts, bromine salts.

    In complex therapy for allergic diseases, neuralgia, with diabetic polyneuropathy, arthritis.

    Contraindications:

    Hypersensitivity to the components that make up the drug.

    Carefully:FROM caution use in children, the experience of using the drug in children is absent.
    Pregnancy and lactation:

    During pregnancy and during lactation, the drug is used solely for life indications.

    Dosing and Administration:Intravenously slowly for 5-10 ml of the solution of 300 mg / ml (depending on the severity of intoxication), with cyanide compounds - 50 ml of a solution of 300 mg / ml.
    Side effects:

    Allergic reactions are possible.

    Overdose:

    Cases of overdose are unknown.

    Interaction:not described
    Special instructions:

    When cyanide poisoning is recommended, the simultaneous administration of sodium hyposulfite and sodium nitrite.

    Effect on the ability to drive transp. cf. and fur:During the treatment period, care must be taken when driving a vehicle and engaging in potentially hazardous activities requiring concentration and speed psychomotor reactions.
    Form release / dosage:

    Solution for intravenous administration 300 mg / ml.

    5 ml or 10 ml in ampoules neutral glass.

    For 10 ampoules with instructions for application and knife for opening ampoules or scarifier The ampoule is placed in a box of cardboard.

    For 5 or 10 ampoules are placed in contour cell packaging from films of polyvinylchloride or polyethylene terephthalate and aluminum foil, or paper with polyethylene coating, or without foil, or without paper.

    1 or 2 contour spinal packages with instructions for application and knife for opening ampoules or a scarifier ampullum is placed in a pack of cardboard.

    When you pack the ampoules with a break ring or break point, the ampoule opener or ampoule scapper is not put in.

    Storage conditions:

    Store in a dark place at a temperature of 5 ° C to 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    5 years. Do not use after the expiration date.

    Terms of leave from pharmacies:On prescription
    Registration number:P N002800 / 01
    Date of registration:08.08.2008
    The owner of the registration certificate:NOVOSIBHIMFARM, OJSC NOVOSIBHIMFARM, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp27.09.2012
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