Sodium thiosulfate (Sodium thiosulfate)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceSodium thiosulfateSodium thiosulfate
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    • Dosage form: & nbspsolution for intravenous administration
    Composition:

    Active substance: sodium thiosulphate pentahydrate - 300 mg;

    Excipients: sodium hydrogen carbonate - 20 mg, water for injection - up to 1 ml.

    Description:

    Transparent colorless liquid.

    Pharmacotherapeutic group:Complexing agent
    ATX: & nbsp

    V.03.A.B   Antidotes

    Pharmacodynamics:

    Sodium thiosulfate is a complexing agent. When introduced into the body has detoxification effect. When poisoning with compounds, arsenic, mercury and lead form non-poisonous sulfites. When poisoned with cyanides, it forms less toxic rhodanous compounds.

    Pharmacokinetics:

    After intravenous administration sodium thiosulfate is distributed into the extracellular fluid. It is excreted from the body with urine.The half-life is 0.65 h.

    Indications:Poisoning by arsenic, mercury, lead, hydrocyanic acid and its salts, iodine and bromine salts.
    Contraindications:

    Hypersensitivity, pregnancy, lactation, children under 18 (due to lack of data).

    Pregnancy and lactation:During pregnancy, the drug is used solely for life indications. During lactation should refrain from breastfeeding.
    Dosing and Administration:

    Intravenously slowly for 5-10 ml of a solution of 300 mg / ml. When poisoning with cyanide compounds, a single dose is increased to 50 ml of a solution of 300 mg / ml.

    Side effects:

    Allergic reactions.

    Overdose:

    Cases of overdose are unknown.

    Interaction:Strongly forbid contact of sodium thiosulfate with nitrates, potassium permanganate.
    Special instructions:

    When cyanide poisoning is recommended the simultaneous administration of sodium hyposulphite and sodium nitrite. It is necessary to carefully monitor the patient within 24-48 h due to the possibility of returning symptoms of cyanide poisoning.

    Effect on the ability to drive transp. cf. and fur:

    No data.

    Form release / dosage:

    Solution for intravenous administration 300 mg / ml.

    Packaging:

    5 or 10 ml into neutral glass ampoules. For 10 ampoules together with the instruction for use and scarifier ampoule in a box of cardboard with a cardboard insert.

    5 ampoules of 5 ml each in a contour mesh package made of PVC.

    Two contour mesh packs together with instruction for use and scapegrator ampullum in a pack of cardboard.

    Storage conditions:

    In the dark place at a temperature of 2 to 30 ° C.

    Keep out of the reach of children.

    Shelf life:

    5 years.

    Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LS-002498
    Date of registration:30.12.2011 / 29.12.2014
    Expiration Date:Unlimited
    The owner of the registration certificate:MIKFARM, LLCMIKFARM, LLC
    Manufacturer: & nbsp
    Information update date: & nbsp25.05.2018
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