Strengthens the depressing effect on the central nervous system of funds for general anesthesia, hypnotics and sedatives, narcotic analgesics and tranquilizers.
Anticoagulants (ardeparin sodium, dalteparin sodium, sodium danaparoid, sodium enoxaparin, heparin sodium, warfarin) increase the risk of bleeding.
When treating the site of injection of a local anesthetic with disinfectant solutions containing heavy metals, the risk of developing a local reaction in the form of tenderness and swelling increases.
When used simultaneously with local anesthetic drugs for epidural anesthesia with guanadrel, guanethidine, mecamylamine, trimetaphan camsylate, the risk of a sharp decrease in blood pressure and bradycardia increases.
Simultaneous use with monoamine oxidase inhibitors (furazolidone, procarbazine, selegiline) increases the risk of a pronounced decrease in blood pressure.
Strengthens and prolongs the action of muscle relaxants.
With the simultaneous use of procaine in conjunction with narcotic analgesics, an additive effect is noted, while respiratory depression is increased. Vasoconstrictors (epinephrine, methoxamine, phenylephrine) extend the local anesthetic effect.
Procaine reduces the effect of antimiasthenic drugs, especially when used in high doses, which requires an additional correction of the treatment of myasthenia gravis.
Cholinesterase inhibitors (antimiasthenic drugs, cyclophosphamide, democaria bromide, eco-iodide iodide, thiotepa) reduce the metabolism of procaine.
Metabolite procaine (paraaminobenzoic acid) is a sulfonamide antagonist.