Novocaine - instructions for use, dose, side effects, contraindications

A local anesthetic with moderate anesthetic activity and a large breadth of therapeutic effect. Being a weak base, it blocks sodium channels, prevents the generation of pulses in the endings of the sensory nerves and impulses along nerve fibers. Changes the action potential in the membranes of nerve cells without pronounced effect on the resting potential. Suppresses carrying out not only pain, but also impulses of another modality.

With absorption and direct vascular injection into the blood flow reduces the excitability of peripheral cholinergic systems, reduces the formation and release of acetylcholine from the preganglionic endings (has a weak ganglion-blocking effect), eliminates spasm of smooth muscles, reduces the excitability of the myocardium and motor cortex of the cerebral cortex.

Pharmacokinetics:

Poorly absorbed through mucous membranes. It is excreted mainly by kidneys in the form of metabolites, in unchanged form it is deduced no more than 2%.

Indications:

Hemorrhoids, cracks in the anus.

Contraindications:

Hypersensitivity (including para-aminobenzoic acid and other local anesthetic esters).

Carefully:

Children's age (up to 12 years), in elderly patients (over 65 years), pregnancy, lactation.

Dosing and Administration:

Rectally.

Preliminarily releasing the suppository from the contour cell package, inject it deep into the anus (after cleansing enema or spontaneous release of the intestine) 1-2 times a day.

Side effects:

Allergic reactions (skin itching, skin rash, urticaria (on the skin and mucous membranes)), dizziness, weakness, lower blood pressure, possible collapse and anaphylactic shock.

Overdose:

Symptoms: pallor of the skin and mucous membranes, dizziness, nausea, vomiting, cold sweats, increased respiration, tachycardia, lowering blood pressure right up to collapse, apnea, methemoglobinemia. Action on the central nervous system is manifested by a feeling of fear, hallucinations, convulsions, motor excitement.

Treatment: maintenance of adequate pulmonary ventilation with inhalation of oxygen,intravenous administration of short-acting drugs for general anesthesia, in severe cases - detoxification and symptomatic therapy.

Interaction:

Local anesthetics increase the inhibitory effect on the central nervous system of other drugs.

Anticoagulants (ardeparin, dalteparin, danaparoid, enoxaparin, heparin, warfarin) increase the risk of bleeding.

Use with monoamine oxidase inhibitors (furazolidone, procarbazine, selegiline) increases the risk of developing hypotension.

Strengthen and prolong the action of myorelaxing drugs.

Vasoconstrictors (epinephrine, methoxamine, phenylephrine) extend the local anesthetic effect.

Procaine reduces the anti-myasthenic action of drugs, especially when used in high doses, which requires an additional correction of the treatment of myasthenia gravis.

Cholinesterase inhibitors (antimiasthenic drugs, cyclophosphamide, demecarine, ecothiophate, thiotepa) reduce the metabolism of local anesthetic drugs.

Metabolite procaine (paraaminobenzoic acid) is a sulfonamide antagonist.

Effect on the ability to drive transp. cf. and fur:

During the period of treatment, care must be taken when driving vehicles and practicing other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Form release / dosage:Suppositories rectal, 100 mg.

Packaging:

5 pieces in a planar cell package.

Two contour mesh packages along with the instruction for medical use of the drug are placed in a cardboard pack.

Storage conditions:

Store in a dry, dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use the drug after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:P N002641 / 01

Date of registration:04.04.2008 / 14.08.2009

Expiration Date:Unlimited

The owner of the registration certificate:NIZHFARM, JSC NIZHFARM, JSC Russia

Manufacturer: & nbsp

NIZHFARM, JSC Russia

Representation: & nbspNizhpharm, JSCNizhpharm, JSCRussia

Information update date: & nbsp25.06.2018

Illustrated instructions

Instructions

Novocaine (Novocaine)