Novocaine - instructions for use, dose, side effects, contraindications

A local anesthetic with moderate anesthetic activity and a large breadth of therapeutic effect. Being a weak base, it blocks sodium channels, displaces calcium from receptors located on the inner surface of the membrane and, thus, prevents the generation of pulses in the endings of the sensory nerves and impulses along nerve fibers. Changes the action potential in the membranes of nerve cells without a pronounced effect on the resting potential. Suppresses carrying out not only pain, but also impulses of another modality.

Pharmacokinetics:

It is subject to complete systemic absorption. The degree of absorption depends on the site and route of administration (especially on vascularization and blood flow velocity in the area of administration) and the final dose (amount and concentration). Rapidly hydrolyzed by esterases of plasma and liver with the formation of two basic pharmacologically active metabolites: diethylaminoethanol (has a moderate vasodilating effect) and paraaminobenzoic acid.

Indications:

Hemorrhoids, cracks in the anus.

Contraindications:

Hypersensitivity (incl.to paraaminobenzoic acid and other local anesthetic esters), children under 14 years of age.

Dosing and Administration:

Rectally. Preliminarily releasing the candle from the contour package using scissors (cutting the package along the contour of the candle), inject it deep into the anus (after cleansing enema or spontaneous release of the intestine) 1-2 times a day.

Side effects:

Allergic reactions: skin itching, skin rash, other anaphylactic reactions (including anaphylactic shock) urticaria (on the skin and mucous membranes); dizziness, weakness, lowering blood pressure.

In these cases, stop using the drug and consult a doctor.

Overdose:

Symptoms: pallor of the skin and mucous membranes, dizziness, nausea, vomiting, cold sweats, increased breathing, tachycardia, lowering blood pressure right up to the collapse. Action on the central nervous system is manifested by a feeling of fear, hallucinations, convulsions, motor excitement.

Treatment: maintenance of adequate pulmonary ventilation with inhalation of oxygen, intravenous administration of short-acting agents for general anesthesia, in severe cases - detoxification and symptomatic therapy.

Interaction:

Local anesthetics increase the inhibitory effect on the central nervous system of other drugs.

Anticoagulants (ardeparin, dalteparin, danaparoid, enoxaparin, heparin, warfarin) increase the risk of bleeding.

Use with monoamine oxidase inhibitors (furazolidone, procarbazine, selegiline), increases the risk of developing hypotension.

Strengthen and prolong the action of myorelaxing drugs.

Cholinesterase inhibitors (antimiasthenic drugs, cyclophosphamide, demecarine, ecothiophate, thiotepa). reduce the metabolism of local anesthetic drugs.

Metabolite procaine (paraaminobenzoic acid) is a sulfonamide antagonist of drugs.

Effect on the ability to drive transp. cf. and fur:

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration.

Form release / dosage:Suppositories rectal, 100 mg.

Packaging:

5 pieces in a planar cell package.

2 contour packs together with instructions for use in a pack of cardboard.

Storage conditions:

In a dry, the dark place at a temperature of no higher than 5 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N001052 / 03

Date of registration:26.11.2007

The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia

Manufacturer: & nbsp

DALHIMFARM, OJSC Russia

Representation: & nbspDALHIMFARM, OJSCDALHIMFARM, OJSC

Information update date: & nbsp03.09.2015

Illustrated instructions

Instructions

Novocaine (Novocaine)