When Nurofen® Plus is used, almost no side effects are observed within 2-3 days. In the case of prolonged use, the following side effects may occur:
From the gastrointestinal tract:
Nausea, vomiting, heartburn, anorexia, pain and discomfort in the epigastrium, diarrhea, flatulence, there may be erosive and ulcerative lesions of the gastrointestinal tract (in some cases complicated by perforation and bleeding), abdominal pain, irritation, dryness of the oral mucosa or pain in the mouth, ulceration of the mucous membrane of the gums, aphthous stomatitis, pancreatitis, constipation, hepatitis.
From the side, the nervous system:
Headache, dizziness, insomnia, agitation, drowsiness, depression, confusion, hallucinations, aseptic meningitis (more often in patients with autoimmune diseases).
From the cardiovascular system:
Heart failure, increased blood pressure (BP), tachycardia.
From the urinary system:
Nephrotic syndrome (edema), acute renal failure, allergic nephritis, polyuria, cystitis.
From the hematopoiesis:
Anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, and leukopenia.
From the sense organs:
Hearing loss, ringing or noise in the ears, reversible toxic optic neuritis, blurred vision or diplopia, dry and irritated eyes, conjunctival edema and eyelids (allergic genesis), scotoma.
Allergic reactions:
Skin rash, itching, urticaria, Quincke's edema, anaphylactoid reactions, anaphylactic shock, fever, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), eosinophilia, allergic rhinitis.
From the respiratory system:
Bronchospasm, shortness of breath, respiratory failure, suppression of the cough center.
Other: increased sweating.
With prolonged use in large doses - ulceration of the mucous membrane of the gastrointestinal tract, bleeding (gastrointestinal, gingival, uterine, hemorrhoidal), visual impairment (violation of color vision, scotoma, amblyopia).
Regular use of codeine leads to the development of dependence, as well as to an excited state and irritability when the drug is withdrawn.
If side effects occur, discontinue use and consult a doctor.