Oxymetazoline - instructions for use, dose, side effects, contraindications

Oxymetazoline is a topical agent. Has vasoconstrictive effect. Oxymetazoline causes narrowing of the vessels of the mucous membranes of the nose, paranasal sinus and Eustachian tube, which leads to a decrease in their edema and the release of nasal breathing in allergic and / or infectious inflammatory rhinitis (runny nose).

According to clinical studies, the drug begins to act for 1 minute, the effect lasts up to 12 hours.

Pharmacokinetics:

When applied as a nasal spray oxymetazoline practically not detected in the blood plasma.

Indications:

Symptomatic therapy of rhinitis (rhinitis) allergiesand / or infectious-inflammatory etiology, treatment of acute respiratory diseases accompanied by a runny nose, sinusitis, eustachiitis, otitis media, hay fever.

To eliminate edema before diagnostic manipulation in the nasal passages.

Contraindications:

Hypersensitivity to sympathomimetic drugs, to any component of the drug, atrophic rhinitis, zakratougolnaya glaucoma, the state after transsphenoidal hypophysectomy, surgical interventions on the dura mater (in the anamnesis), simultaneous use of monoamine oxidase inhibitors (including the period of 14 days after their withdrawal), children's age to 6 years.

Carefully:

Coronary artery disease, arrhythmias, tachycardia, chronic heart failure, severe atherosclerosis, arterial hypertension, hyperthyroidism, diabetes mellitus, pheochromocytoma, chronic renal failure, increased intraocular pressure, prostatic hyperplasia with clinical symptoms, porphyria, pregnancy, the period of breastfeeding.

When therapy with tricyclic antidepressants, as well as other drugs that increase blood pressure.

Pregnancy and lactation:

Safety of the drug in pregnant women and during breastfeeding is not established,so the drug should be administered to pregnant or breast-feeding only on doctor's advice if the expected benefits of the drug to the mother outweighs the potential risk to the fetus or infant.

Dosing and Administration:

Intranasally.

Before each use, vigorously shake the spray bottle.

Before the first application of the nasal spray, it is necessary to "calibrate" it by pressing the spray head several times.

Adults and children over 6 years of age - 1 injection in each nasal passage with an interval of 10-12 hours. Multiplicity of application can be increased up to 3 times a day in adults. Do not exceed the specified dose.

Side effects:

In general, the drug is well tolerated, and possible adverse events are usually mild and transient.

Transient dryness and stinging of the nasal mucosa, dry mouth and throat, sneezing, nose bleeding; increased blood pressure, increased anxiety, nausea, dizziness, headache, convulsions, insomnia, palpitations, sleep disorders, drowsiness, restlessness, hallucinations, fatigue; Exanthema, Quincke's edema, itching; visual impairment (eye contact).

With prolonged use - tachyphylaxis, reactive hyperemia and atrophy of the mucous membrane of the nasal cavity.

Overdose:

With a significant overdose or accidental ingestion possible: nausea, vomiting, cyanosis, fever, tachycardia, arrhythmia, increased blood pressure, dyspnea, mental disorders, central nervous system depression (drowsiness, lower body temperature, bradycardia, lowering blood pressure, stopping breathing and coma).

Treatment: symptomatic. At casual reception inside - gastric lavage, Activated carbon.

Vasopressor drugs are contraindicated.

Interaction:

Slows the absorption of local anesthetic drugs, lengthens the time of their action.

In patients taking monoamine oxidase inhibitors (MAO) for the previous 2 weeks and within 2 weeks after their withdrawal, tricyclic antidepressants, or other drugs that increase blood pressure - increase blood pressure.

Co-administration of other vasoconstrictive drugs increases the risk of side effects.

Special instructions:With prolonged use (more than one week), it is possible to resume symptoms of nasal congestion.

If you need to continue treatment for more than 5 days, you need to consult a doctor.

Avoid contact with the eye.

Effect on the ability to drive transp. cf. and fur:

After a prolonged use of funds from the cold, containing oxymetazoline, in doses exceeding the recommended, one can not exclude the general effect on the cardiovascular system and the central nervous system. In these cases, it is advisable to use caution when driving vehicles and engaging in other potentially hazardous activities requiring increased attention and speed of psychomotor reactions.

Form release / dosage:

Spray nasal, 0.05%.

Packaging:

10 ml per bottle of white polyethylene, equipped with a pump-sprayer with a protective cap. Each label is labeled or labeled with a quick-fixing paint.

On 1 bottle together with the instruction on application place in a pack a cardboard.

Storage conditions:

Store at a temperature not exceeding 25 ° C. Do not freeze.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-003901

Date of registration:11.10.2016

Expiration Date:11.10.2021

The owner of the registration certificate:ALVILS, LTD. ALVILS, LTD. Russia

Manufacturer: & nbsp

NANJING TIANLANG PHARMACEUTICAL Co., Ltd. China

Representation: & nbspAlvils, OOOAlvils, OOO

Information update date: & nbsp24.05.2017

Illustrated instructions

Instructions

Oxymetazoline (Oxymetazoline)