Clinical and pharmacological group: & nbsp
Laxatives
Included in the formulation
АТХ:A.06.A.B.08 Sodium picosulphate
Pharmacodynamics:Strengthens peristalsis, as a result of accelerated the movement of intestinal contents and decreases the absorption of electrolytes and water. The laxative effect develops 6-12 hours after ingestion.
Pharmacokinetics:Absorption for oral and rectal administration is minimal. Biotransformation by intestinal and bacterial enzymes into the active metabolite. Elimination by the kidneys and with feces.
Indications:- constipation of various etiologies (hypotension and flaccid peristalsis of the colon with a change in the nature of nutrition, during pregnancy, after surgery, with prolonged bed rest, metabolic disorders, obesity);
- hemorrhoids, proctitis and anal fissures;
- preparation for surgical operations, radiology or endoscopy gastrointestinal tract, urography, radiography of the lumbosacral spine.
IX.I80-I89.I84 Hemorrhoids
XI.K55-K63.K59.0 Constipation
XI.K55-K63.K60 Fissure and fistula of the anus and rectum area
XXI.Z40-Z54.Z51.4 Preparatory procedures for subsequent treatment, not elsewhere classified
Contraindications:- individual intolerance;
- intestinal obstruction;
- strangulated hernia;
- acute inflammatory diseases of the abdominal cavity;
- peritonitis;
- abdominal pain of unknown origin;
- severe dehydration;
- bleeding from the gastrointestinal tract;
- uterine bleeding;
- cystitis;
- spastic constipation;
- children's age (up to 4 years);
- pregnancy (I trimester).
Carefully:Breast-feeding.
Pregnancy and lactation:The category of FDA recommendations is not defined. Contraindicated during the first trimester. With caution during breastfeeding.
Dosing and Administration:Preparation for colorectal surgery - 10 mg a day before surgery, in the morning and after noon.
Purification of the intestine - inside, the initial dose of 10 drops (5-10 mg) before bedtime, an average of 12-24 drops, with heavy and persistent constipation up to 30 drops. The onset of laxative action (if ingested) after 6-12 hours.
Side effects:Rarely: allergic reactions, electrolyte disorders, intestinal colic.
Digestive system: nausea, vomiting.
Others: skin rash, weakness.
Long-term admission: eructation, diarrhea, nausea, rectal irritation (proctitis with rectal administration), electrolyte disorders (hypokalemia), intestinal atony.
Overdose:When an overdose is observed liquid stools and paroxysmal pain in the abdomen. Treatment: gastric lavage, correction of water-electrolyte balance disorders, spasmolytic preparations.
Interaction:Antibiotics of a wide spectrum reduce the laxative effect.
Diuretics, glucocorticoids provoke a risk of electrolyte disorders.
Special instructions:It is not recommended to use more than 10 days without medical supervision.