Betacarotene (Betacarotenum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Vitamins and vitamin-like remedies

Included in the formulation
  • Carolyn®
    solution inwards externally 
    ROSKARFARM, CJSC     Russia
    • АТХ:

    A.11.C.A.02   Betacarotene

    Pharmacodynamics:

    The drug is a carotenoid, a precursor of vitamin A. It has an antioxidant effect, it has the ability to inactivate free radicals under hypoxic conditions.

    Protects the skin from the harmful effects of ultraviolet rays, has an anti-xerophthalmic effect.

    Betacarotene has an immunomodulating effect, apparently stimulating the differentiation of B- and T-lymphocytes.

    Participates in the processes of regeneration of epithelial tissues and increases their resistance to infections.

    Pharmacokinetics:

    Absorption at ingestion - fast and complete.

    Metabolised in the liver with the formation of active forms of vitamin A, which bind to the retinol transport protein and are delivered to various organs and tissues. In the presence of zinc ions In the liver, inactive products are formed.

    It is excreted by the kidneys and with bile.

    Indications:

    Prevention and treatment of vitamin A deficiency.

    To increase nonspecific resistance of the organism under the influence of small radiation doses, X-ray examination, radiation and chemotherapy in oncology, laser therapy, immunodeficiency states, contact with pesticides.

    Age-related macular degeneration.

    As part of complex therapy: peptic ulcer of the stomach and duodenum, erosive gastritis, duodenitis, nonspecific ulcerative colitis, a dysbacteriosis; nonspecific diseases of the lungs and upper respiratory tract; wounds, burns, frostbites, trophic ulcers; polymorphic photodermatosis, vitiligo, local skin pigmentation, hyperpigmentation.

    ICD-10

    IV.E50-E64.E50   Insufficiency of vitamin A

    VII.H30-H36.H35.3   Degeneration of the macula and posterior pole

    IX.I80-I89.I83.2   Varicose veins of the lower extremities with ulcer and inflammation

    X.J00-J06.J06.9   Acute upper respiratory tract infection, unspecified

    XI.K20-K31.K25   Stomach ulcer

    XI.K20-K31.K26   Duodenal ulcer

    XI.K20-K31.K29   Gastritis and duodenitis

    XI.K50-K52.K50   Crohn's disease [regional enteritis]

    XI.K50-K52.K51   Ulcerative colitis

    XI.K55-K63   Other bowel diseases

    XII.L55-L59.L56.2   Photocontact dermatitis [berloque dermatitis]

    XII.L80-L99.L81   Other disorders of pigmentation

    XIX.T08-T14.T14.1   Open wound of unspecified area of ​​the body

    XIX.T20-T32.T30   Thermal and chemical burns, unspecified

    XIX.T33-T35.T33   Surface frostbite

    Contraindications:

    Hypersensitivity, hypervitaminosis A, alcoholism, liver cirrhosis, viral hepatitis, impaired renal function.

    Carefully:

    Metabolic disorders.

    Pregnancy and lactation:

    The category of FDA recommendations is not defined. Adequate and well-controlled studies on humans and animals have not been conducted. There is no information on the penetration of betacaren in breast milk. Apply in pregnancy and lactation strictly according to the indications under the supervision of a doctor.

    Dosing and Administration:

    Inside, externally. Doses of the drug and the frequency of reception depend on the disease.

    With the prophylactic purpose daily inside 0,01-0,03 g per day (during or after meals); if necessary, increase the dose to 0.065 g per day.

    Pregnant - daily at 0.01 g per day. For the treatment of polymorphic photodermatoses and skin pigmentation anomalies - 0,03-0,18 g per day; for prophylaxis - at 0.01 g per day. The course of treatment is from 3-6 to 12 months and more.

    Application in children: Inside. 1-5 years: 60-90 mg per day in one or more meals with food. 5-9 years: 90-120 mg per day in one or more meals with food. 9-12 years: 120-150 mg per day in one or more meals with food. 12-16 years: 150-180 mg per day in one or more meals with food. 16-18 years: 180-300 mg per day in one or more meals with food. Protection is incomplete, to develop the effect, usually 2-6 weeks of treatment is needed (leads to yellow staining of the palms and feet).

    Side effects:

    Manifestations of hypervitaminosis A: headache, dizziness, weakness, anxiety, double vision, dyspeptic disorders, skin rashes, dry lips, pain in bones and joints, anorexia, ulceration of the skin and mucous membranes.

    Overdose:

    Symptoms: Headache, dizziness, weakness, anxiety, double vision, dyspepsia, loosening of the stool, skin rashes, hemorrhages, dry lips, pain in the bones and joints, decreased appetite, ulceration of the skin and mucous membranes.

    Excessive consumption of beta-carotene does not lead to hypervitaminosis A.

    Treatment: symptomatic. Immediately stop taking the drug.

    Interaction:

    Preparations of calcium, colestramine, mineral oils, neomycin, Vitamin E reduce suction.

    Special instructions:

    According to the biological activity, 1 mg of β-carotene corresponds to 0.167 mg (556 U) of retinol.

    Partially in the body turns into retinol, necessary for the normal functioning of the retina (provides the transition opsin to rhodopsin - a pigment that provides night vision).

    It is not represented in the United States Pharmacopeia.

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