associated with rifampicin.
From the digestive system: nausea, vomiting, diarrhea, increased levels of "liver" transaminases, hyperbilirubinemia, decreased appetite, erosive gastritis, pseudomembrane enterocolitis, hepatitis.
From the side of the central nervous system and sensory organs: headache, impaired coordination of movements, visual impairment, disorientation.
From the urinary system: interstitial nephritis.
Allergic reactions: skin rash, itching, swelling of the Quincke, bronchospasm; fever,
urticaria, eosinophilia.
Other: arthralgia; rarely - leukopenia, menstrual irregularity, dysmenorrhea, induction of porphyria, muscle weakness, hyperuricemia, exacerbation of gout.
associated with isoniazid.
From the digestive system: nausea, vomiting, constipation, a rapidly increasing activity of "liver" transaminases in the blood plasma during the first month of treatment, gastralgia, toxic hepatitis. Rare persistent increase in enzyme activity is rare.
From the side of the central nervous system: headache, dizziness, rarely - unusual fatigue or weakness, irritability, euphoria, mood changes, depression. Epileptic patients may experience seizures.When using high doses of isoniazid - peripheral neuropathy, manifested paresthesia of the skin of the hands; hyperreflexia, tremor, convulsions, toxic encephalopathy, toxic psychosis; insomnia; neuritis and atrophy of the optic nerve.
From the cardiovascular system: palpitation, angina, increased blood pressure.
On the part of the hematopoiesis system: agranulocytosis, hemolytic, sideroblastic and aplastic anemia; thrombocytopenia, eosinophilia.
From the side of the hemostasis system: acidosis.
Allergic reactions: "lupus-like" syndrome, skin rash, purpura, lymphadenopathy, vasculitis, itching, hyperthermia, arthralgia.
Other: very rarely - gynecomastia, menorrhagia, a tendency to bleeding and hemorrhage.
associated with vitamin B6.
Allergic reactions.
When receiving an irregular or when resuming treatment after a break can flu-like syndrome (fever, chills, headache, dizziness, myalgia), skin reactions, hemolytic anemia, thrombocytopenic purpura, acute renal failure.
Overdose
Rifampicin.
Symptoms: pulmonary edema, lethargy, confusion, convulsions.
Treatment: symptomatic; gastric lavage, the appointment of activated charcoal; forced diuresis.
Isoniazid.
Symptoms: dizziness, dysarthria, lethargy, disorientation, hyperreflexia, peripheral polyneuropathy, abnormal liver function, metabolic acidosis, gyrrlikemia, glucosuria, ketonuria, seizures (1-3 hours after drug administration), coma.
Treatment: peripheral polyneuropathy (vitamins B6, B1, B12, ATP, glutamic acid, nicotinamide, massage, physiotherapy procedures); convulsions - (in / m vitamin B6 - 200-250 mg, iv 40% dextrose solution - 20 ml, in / m 25% magnesium sulfate solution - 10 mg, diazepam); abnormal liver function (methionine, lipid, ATP, vitamin B12).