Related to rifampicin:
From the digestive system: nausea, vomiting, diarrhea, decreased appetite, erosive gastritis, pseudomembranous enterocolitis; increase in the level of "hepatic" transaminases in the serum, hyperbilirubinemia, hepatitis.
From the central nervous system: headache, impaired coordination of movements, reduced visual acuity, disorientation.
From the urinary system: nephronecrosis, interstitial nephritis.
Allergic reactions: skin rash, itching, Quincke's edema, bronchospasm, fever, urticaria, eosinophilia.
Other: arthralgia; rarely - leukopenia, menstrual irregularity, induction of porphyria, muscle weakness, hyperuricemia, exacerbation of gout.
Isoniazid-related:
From the digestive system: nausea, vomiting, constipation, a rapidly increasing activity of "liver" transaminases in the blood plasma during the first month of treatment, gastralgia, toxic hepatitis. Rarely - persistent increase in enzyme activity.
From the central nervous system: headache, dizziness, rarely excessive fatigue or weakness, irritability, euphoria, mood changes, depression. Epileptic patients may experience seizures. When using high doses of isoniazid - peripheral neuropathy, manifested by paresthesias of the skin of the hands, feet; hyperreflexia, tremor, convulsions, toxic encephalopathy,psychosis; insomnia; neuritis and atrophy of the optic nerve.
From the cardiovascular system: palpitation, angina, increased blood pressure.
On the part of the hematopoiesis system: agranulocytosis, hemolytic, sideroblastic and aplastic anemia; thrombocytopenia, eosinophilia.
From the side of the hemostasis system: acidosis.
Allergic reactions: skin rash, itching, hyperthermia, "lupus-like" syndrome, purpura, lymphadenopathy, vasculitis, arthralgia.
Other: very rarely - gynecomastia, menorrhagia, a tendency to bleeding and hemorrhage.
With an irregular reception or with the resumption of treatment after a break, flu-like syndrome (fever, chills, headache, dizziness, myalgia), skin reactions, hemolytic anemia, thrombocytopenic purpura, acute renal failure are possible.
Associated with pyridoxine:
Allergic reactions.