Hypersensitivity to the drug, spastic constipation, spastic colitis, acute inflammatory diseases of the abdominal cavity organs, appendicitis, intestinal obstruction, strangulated hernia, perforated ulcer, proctitis and hemorrhoids (exacerbation phase), abdominal pain of unknown origin, metrorrhagia, gastrointestinal bleeding, cystitis, disturbed water-electrolyte metabolism, pregnancy, the period of breastfeeding, children under 12 years.