Adults and children over 12 years of age: for 1-2 g of Sulperacef® (respectively, 0.5-1 g of cefoperazone and 0.5-1 g of sulbactam) every 12 hours. In severe, life-threatening infections - 4 g (2 g of cefoperazone and 2 g of sulbactam) iv every 12 hours.
The maximum daily dose of sulbactam should not exceed 4 g. Patients receiving the drug in a 1: 1 ratio may require additional administration of cefoperazone.
In patients with severe renal insufficiency dose adjustment is required. When creatinine is cleared, 15-30 ml / min Sulperacef® is administered 1 g every 12. h .; when creatinine clearance is less than 15 ml / min - 0.5 g every 12 hours. In severe infections, additional administration of cefoperazone may be required. In patients on hemodialysis, Sulperacef® is administered immediately after the end of the dialysis session.
Dose change when liver function is impaired may be required only in cases of severe obstruction of the biliary tract and severe liver disease, as well as in patients with a combination of hepatic and renal insufficiency.In these cases it is recommended to monitor the serum concentration of cefoperazone and correct its dose if necessary. If regular monitoring of serum concentration of cefoperazone is impossible, then its daily dose should not exceed 2 g.
Have children from 1 month to 12 years the daily dose of Sulperfatef® is 40-80 mg / kg, which is divided into 2-4 injections at intervals of 6-12 hours. For the treatment of severe infections, the dose is increased to 160 mg / kg per day.
Have newborns the maximum daily dose of sulbactam should not exceed 80 mg / kg / day; During the first week of life, the drug should be injected every 12 hours. Rules for the preparation of solutions
To prepare a solution for intravenous administration, 0.5 and 1 g of Sulpercef® are dissolved in 10 ml, and 2 g in 20 ml of water for injection or 0.9% of sodium chloride solution. Enter iv slowly, for 3-5 min; it is possible to administer through the injection unit (into the "eraser") a system for intravenous infusions with transfusion of compatible solutions.
Day of / in drip infusion 0.5 and 1 g of Sulperfatef® are dissolved in 10-20 ml of sterile water for injection or 0.9% solution of sodium chloride; after complete dissolution, the resulting solution is added to 50-100 ml of a 0.9% solution of sodium chloride or a 5% solution of dextrose; injected intravenously drip,using a system for intravenous infusion.
For the / m introduction, a 2% solution of lidocaine hydrochloride (in the absence of allergies to local anesthetics!), But it can not be used for the primary dilution of the powder. Therefore, the solution is prepared in two stages. For primary dilution, use sterile water for injection in the volumes indicated below:
0.5 g of Sulperfatsef® 1.5 ml
1.0 g of Sulperfatsef® 2.4 ml
2.0 g of Sulperfatsef® 4.7 ml
Then, the resulting solution is diluted with a 2% solution of lidocaine, adding 0.5 ml, 1 ml and 2 ml of a local anesthetic to a dilution solution containing 0.5 g, 1 g or 2 g of Sulpercef®, respectively, in order to obtain an antibiotic solution in 0.5% solution of lidocaine hydrochloride. Enter deeply intramuscularly into areas of the body with a pronounced muscular layer (for example, the upper-outer quadrant of the buttock).