Intravenous (struino and drip) and intramuscularly.
Application in adults
In adults cefoperazone + sulbactam it is recommended to use in the following daily doses:
| Ratio | cefoperazone and sulbactam dose (g) | sulbactam dose (g) | cefoperazone dose (g) |
| 1:1 | 2,0-4,0 | 1,0-2,0 | 1,0-2,0 |
The daily dose should be divided into equal parts and administered every 12 hours. With severe and resistant to standard doses of infections, the daily dose of cefoperazone + sulbactam can be increased to 8 g at a ratio of the main components of 1: 1 (ie 4 g of cefoperazone). If you need more than 8 g (with a 1: 1 ratio of the main components), an increase in the dose is achieved by the additional administration of cefoperazone. The dose should be divided into equal parts and administered every 12 hours. The recommended maximum daily dose of sulbactam is 4 g.
Application for renal dysfunction
In patients with creatinine clearance of 15-30 ml / min, the maximum dose of sulbactam is 1 g every 12 hours (maximum daily dose of sulbactam 2 g), and in patients with creatinine clearance less than 15 ml / min the maximum dose of sulbactam is 500 mg every 12 hours the maximum daily dose of sulbactam 1 g). In severe infections, additional administration of cefoperazone may be required.
The pharmacokinetics of sulbactam significantly changes during hemodialysis. The half-life of cefoperazone from the blood plasma is somewhat reduced during hemodialysis. Therefore, the administration of the drug should be planned after dialysis.
Application for violations of liver function
If regular monitoring of serum concentration of cefoperazone is not performed, the maximum daily dose should not exceed 2 g (see section "Special instructions"). Use in children
Children cefoperazone + sulbactam it is recommended to use in the following daily doses:
| The dose ratio (mg / kg / day) | cefoperazone + sulbactam dose (mg / kg / day) | sulbactam | cefoperazone |
| 1:1 | 40-80 | 20-40 | 20-40 |
The dose should be divided into equal parts and administered every 6-12 hours.
With severe and resistant to standard doses of infections, the daily dosecan be increased to 160 mg / kg / day at a ratio of the main components of 1: 1. The daily dose is divided into 2-4 equal parts. If you need more than 80 mg / kg / day, calculated from the activity of cefoperazone, an increase in dose is achieved through the additional administration of cefoperazone.
Neonatal application
In newborns be administered every 12 hours. The maximum daily dose of sulbactam in children should not exceed 80 mg / kg / day during the first week of life of the drug.
Method of preparing solutions for parenteral use
Breeding:
| Total dose (g) | Equivalent doses cefoperazone + sulbactam | Volume of solvent, ml | Maximum final concentration, mg / ml |
| 1,0 | 0,5 + 0,5 | 3,4 | 125+125 |
| 2,0 | 1,0+1,0 | 6.7 | 125+125 |
Intramuscular administration:
Sterile water for injection is used for dissolution (see table). If the drug is administered at a concentration in excess of 250 mg / ml, it is recommended to prepare the solution using lidocaine. Dilution is carried out in 2 stages - in a vial containing 1 g of the drug, add 1.3 ml of sterile water for injections, in a vial containing 2 g - 2.6 ml, shake until completely dissolved, and then add to a vial containing 1 g 0.4 ml, into a vial containing 2 grams of 0.8 ml of a 2% solution of lidocaine hydrochloride.The final solution will contain in 1 ml of a 0.5% solution of lidocaine hydrochloride about 250 mg of cefoperazone and about 250 mg of sulbactam.
Intravenous administration:
For IV administration, the contents of the vial are dissolved in an adequate volume (see table) 5% dextrose solution, 0.9% sodium chloride solution, 5% dextrose solution in 0.225% sodium chloride solution, 5% dextrose solution in 0.9% sodium chloride solution or sterile water for injection and injected for 3 minutes.
For IV infusion introduction dissolve, as mentioned above, then dilute to 20-100 ml with the same solvent and injected for 15-60 minutes.
Preparation of the solution using Ringer's lactate. Since Ringer's lactate is not suitable for initial dilution, the solution is prepared in two steps: first use sterile water for injection (see table), and then dilute the resulting solution Ringer's lactate solution to a concentration of 5 mg / ml of sulbactam. Infusion is carried out for 15-60 minutes.