Intravenous (struino and drip) and intramuscularly.
The dose of cefoperazone + [sulbactam] depends on the severity of the disease, type of infection, body condition, age, body weight and kidney function in the patient.
Application in adults
In adults cefoperazone+ [sulbactam] is recommended for use in the following daily doses:
Ratio cefoperazone+ [sulbactam] sulbactam dose (g) cefoperazone dose (g)
dose (g)
1:1 2,0 - 4,0 1,0-2,0 1,0-2,0
The daily dose should be divided into equal parts and administered every 12 hours. In severe and refractory infections, the daily dose of cefoperazone + [sulbactam] can be increased to 8 g with a 1: 1 ratio of the major components (ie 4 g of cefoperazone). If you need more than 8 g (with a 1: 1 ratio of the main components), an increase in the dose is achieved by the additional administration of cefoperazone. The dose should be divided into equal parts and administered every 12 hours. The recommended maximum daily dose of sulbactam is 4 g.
Application for renal dysfunction
In patients with creatinine clearance of 15-30 ml / min, the maximum dose of sulbactam is 1 g every 12 hours (maximum daily dose of sulbactam 2 g), and in patients with creatinine clearance less than 15 ml / min the maximum dose of sulbactam is 500 mg every 12 hours the maximum daily dose of sulbactam 1 g). In severe infections, additional administration of cefoperazone may be required.
The pharmacokinetics of sulbactam significantly changes during hemodialysis. The half-life of cefoperazone from the blood plasma is somewhat reduced during hemodialysis. Therefore, the administration of the drug should be planned after dialysis.
Application for violations of liver function
If regular monitoring of serum concentration of cefoperazone is not performed, the maximum daily dose should not exceed 2 g (see section "Special instructions").
Use in children
Children cefoperazone+ [sulbactam] is recommended for use in the following daily doses:
Ratio cefoperazone+ [sulbactam] sulbactam cefoperazone
dose (mg / kg / day) dose (mg / kg / day) dose (mg / kg / day)
1:1 40-80 20-40 20-40
The dose should be divided into equal parts and administered every 6-12 hours.
In severe and refractory infections, the daily dose can be increased to 160 mg / kg / day with a 1: 1 ratio of the major components. The daily dose is divided into 2-4 equal parts. If you need more than 80 mg / kg / day, calculated from the activity of cefoperazone, an increase in dose is achieved through the additional administration of cefoperazone.
Neonatal application
In newborns be administered every 12 hours. The maximum daily dose of sulbactam in children should not exceed 80 mg / kg / day during the first week of life of the drug.
Method of preparing solutions for parenteral use
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| Total dose | Equivalent doses | Size | ultimate |
| (d) | cefoperazone + [sulbactam] | solvent, ml | concentration, |
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| mg / ml |
| 0,5 | 0,25 + 0,25 | 1,7 | 125+125 |
| 1,0 | 0,5 + 0,5 | 3,4 | 125 + 125 |
| 2,0 | 1,0+1,0 | 6,7 | 125 + 125 |
Intramuscular administration (in / m):
Sterile water for injection is used for dissolution (see table). If the drug is administered with a concentration of cefoperazone exceeding 250 mg / ml, it is recommended to prepare the solution using a lidocaine solution. Dilution is carried out in 2 stages - in a bottle containing 0.5 g of the drug, add 0.65 ml of sterile water for injection (in a vial containing 1 g - 1.3 ml,containing 2 g - 2.6 ml), shaken until complete dissolution, and then 0.2 ml of a 2% solution of lidocaine (in a vial containing 1 g of the drug - 0.4 ml, into a vial containing 2 g - 0.8 ml). The final solution will contain in 1 ml of a 0.5% solution of lidocaine about 250 mg of cefoperazone and about 250 mg of sulbactam.
Intravenous (iv):
For intravenous administration, the contents of the vial are dissolved in an adequate volume (see table) 5% dextrose solution, 0.9% sodium chloride solution, 5% dextrose solution in 0.225% sodium chloride solution, 5% dextrose solution in 0.9% sodium chloride solution or sterile water for injections and injected for 3 minutes.
For intravenous infusion introduction, dissolve, as mentioned above, then dilute to 20-100 ml with the same solvent and injected for 15-60 minutes.
Preparation of the solution using Ringer's solution of lactate. Since Ringer's lactate solution is not suitable for initial dilution, the solution is prepared in two steps: first use sterile water for injection (see table) and then dilute the resulting solution with Ringer's lactate solution to a concentration of 5 mg / ml of sulbactam. Infusion is carried out for 15-60 minutes.