Intravenous (jet and drip), intramuscularly.
Adults - 1-2 g of the drug every 12 hours. In severe infections, the daily dose of cefoperazone + sulbactam can be increased to 8 g with a 1: 1 component ratio (ie 4 g of cefoperazone). Patients receiving
cefoperazone + sulbactam in a ratio of 1: 1, additional administration of cefoperazone may be required. The dose should be divided into equal parts and administered every 12 hours.
The recommended maximum daily dose of sulbactam is 4 g.
In patients with SC 15-30 ml / min, the maximum dose of sulbactam is I g every 12 hours (maximum daily dose of sulbactam 2 g), and in patients with QC less than 15 ml / min the maximum dose of sulbactam is 500 mg every 12 hours (maximum daily dose of sulbactam I g). In severe infections, additional administration of cefoperazone may be required.
The pharmacokinetics of sulbactam significantly changes during hemodialysis, the half-life of cefoperazone from serum decreases slightly, so the drug should be administered after dialysis.
If regular monitoring of serum concentration of cefoperazone is not performed, the maximum daily dose should not exceed 2 g.
The dose should be divided into equal parts and administered every 6-12 hours.
For serious or refractory infections, these dosages can be increased to 160 mg / kg / day for a 1: 1 component ratio. The daily dose is divided into 2-4 equal parts. If it is necessary to introduce more than 80 mg / kg / day, calculated on the activity of cefoperazone, an increase in the dose is achieved due to the additional administration of cefoperazone.
PChanging the the newborns
In newborns be administered every 12 hours. The maximum daily dose of sulbactam in children should not exceed 80 mg / kg / day during the first week of life of the drug. A method for preparing solutions of a parenteral atchange
Breeding:
| Total dose, g | The equivalent dose cefoperazone + sulbactam, g | Volume of solvent, ml | Maximum final concentration, mg / ml |
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| 0.5 | 0.25 g 0.25 | 1,7 | 125 + 125 |
| 1,0 | 0.5 + 0.5 | 3.4 | 125 + 125 |
| 2.0 | 1,0 + 1.0 | 6.7 | 125 + 125 |
Intramuscular administration:
Sterile water for injection is used for dissolution (see table). If the drug is administered at a concentration in excess of 250 mg / ml, it is recommended to prepare the solution using lidocaine. Dilution is carried out in 2 stages - in a vial containing 0.5 g of the drug,add 0.65 ml of sterile water for injection (in a vial containing 1 g of the drug - 1.3 ml, in a vial containing 2 g - 2.6 ml), agitate until completely dissolved, and then add 0.2 ml of a 2% solution of lidocaine hydrochloride (per vial , containing 1 g of the drug - 0.4 ml, in a vial containing 2 g - 0.8 ml). The final solution will contain in 1 ml of a 0.5% solution of lidocaine hydrochloride about 250 mg of cefoperazone and about 250 mg of sulbactam.
ATnutritional administration:
For IV introduction, the contents of the vial are dissolved in an adequate volume (see table) of 5% dextrose solution, 0.9% solution NaCL 5% dextrose solution in 0.225% solution NaCl, 5% dextrose solution in 0.9% solution NaCl or sterile water for injection, and injected for 3 minutes.
For IV infusion introduction dissolve, as mentioned above, then dilute to 20-100 ml with the same solvent and injected for 15-60 minutes:
Preparation of the solution using Ringer's lactate.
Since Ringer's lactate is not suitable for initial dilution, the solution is prepared in two steps: first use a sterile injectable oxal (see table) and then dilute the resulting solution with Ringer's lactate solution to a 5 mg / ml sulbactam concentration. Infusion is carried out for 15-60 minutes.