Timolol - instructions for use, dose, side effects, contraindications

Antiglaucomatisant. Refers to a group of beta-blockers. Warns stimulating the effect of catecholamines on beta-adrenergic receptors. With topical application in the form of eye drops reduces intraocular pressure due to the reduction of the formation of watery moisture. Localization of the action of timolol - beta-2 adrenoreceptors in the ciliary body. The effect manifests itself 20 minutes after instillation, the maximum effect 'comes in 1-2 hours, the duration of the action is 10-20 hours.

Pharmacokinetics:

Timolol maleate quickly penetrates through the pigment into the tissues of the eye.In an insignificant amount, it enters the systemic bloodstream through absorption through the conjunctiva, the nasal mucosa and the lacrimal tract. Excretion of metabolites by the kidneys. In newborns and small children

children, the concentration of the active substance is significantly higher than its Stach in adult plasma.

Indications:

open angle glaucoma, secondary

glaucoma (uveal, aphakic, posttraumatic), acute ophthalmotonus, closed-angle glaucoma (in combination with miotics).

Contraindications:

Dystrophic diseases of the cornea, rhinitis, bronchial asthma, chronic obstructive bronchitis, sinus bradycardia (50 or less beats per minute), AV blockade II and III degree, acute and chronic heart failure, cardiogenic shock, hypersensitivity to timolol maleate. :

Carefully:

pulmonary insufficiency, severe

cerebrovascular insufficiency, chronic heart failure, diabetes mellitus, hypoglycemia, thyrotoxicosis, myasthenia gravis, simultaneous appointment other beta-

adrenoblockers. With special care, appoint newborns and premature babies.

Pregnancy and lactation:

In pregnancy, the drug is used if the expected benefit to the mother exceeds the potential risk to the fetus. During the use of the drug, breastfeeding should be discontinued.

Dosing and Administration:

Locally, in a single dose - 1 drop of 0.25% solution to the affected

eye, frequency of application - 1-2 times a day. With insufficient efficiency, use a 0.5% solution. With the normalization of intraocular pressure, the maintenance dose - 1 drop of 0.25%

solution once a day.

Side effects:

Local reactions: hyperemia of the skin of the eyelids, burning and itching in the eyes,

lacrimation, photophobia, conjunctival hyperemia, conjunctivitis, corneal epithelial edema, short-term visual acuity, decreased corneal sensitivity, ptosis, diplopia. Systemic reactions: bradycardia, bradyarrhythmia, lowering of arterial pressure, dizziness, nausea, headache, muscle weakness, insomnia, decreased potency, transient cerebral circulation, bronchospasm, collapse, AV blockade, cardiac arrest, shortness of breath, pulmonary insufficiency, worsening of manifestations of heart failure , bronchospasm; paresthesia, rhinitis, nasal congestion,nose bleed; allergic reactions (urticaria).

Overdose:

When topical application in the recommended dose, the symptoms of an overdose were not noted. With the occasional ingestion, the following symptoms may develop: nausea, vomiting, headache

pain, dizziness, lowering of arterial pressure, bronchospasm, bradycardia. In case of symptoms of overdose, treatment is symptomatic. Isoprenaline can be administered intravenously to eliminate severe bradycardia or bronchospasm, dobutamine for the treatment of arterial hypotension.

Interaction:

When used with reserpine - it is possible to develop severe bradycardia or hypotension (this combination requires careful medical supervision); with calcium channel blockers or cardiac glycosides - there may be a violation of AV conduction, acute left ventricular failure or arterial hypotension. Epinephrine, pilocarpine, systemic beta-blockers increase the effect of the drug. Timolol enhances the effect of muscle relaxants (the drug should be discontinued 48 hours before the general anesthesia).

Special instructions:

Control of efficacy is recommended to be carried out approximately 3-4 weeks after the start of therapy. During the treatment period, at least once every 6 months, the function of lacrimation, the integrity of the cornea, and the field of vision should be monitored.

Take care when driving at night. Contact lenses should be removed before instillation and put on not earlier than 15 minutes after it.

Do not bother with 2 beta-blockers at the same time.

With prolonged use of timolol, the effect may be weakened. When transferring patients to treatment with timolol, correction of refraction may be necessary.

Before the forthcoming surgical intervention with the application of general anesthesia - within 48 hours the drug should be canceled

Form release / dosage:

Eye drops 0.25%, 0.5% solution in vials, bottles of orange glass, bottles of droppers of polytetene by 1 or 5 mg, 1 or 5 bottles per pack.

Packaging:

(1) - bottle-dropper polymer (1) - packs cardboard
(1) - bottle-dropper polymer (5) - packs cardboard
(1) - bottle-dropper polymer (50) - cardboard boxes
(1) - vials (1) / complete with lid-dropper / - packs cardboard
(1) - bottles (5) / complete with lid-dropper-5 pcs. / - packs cardboard
(1) - bottles (50) - cardboard boxes
(1) - bottles of dark glass (1) / complete with lid-dropper / - packs cardboard
(1) - bottles of dark glass (5) / complete with lid-dropper-5 pcs. / - packs cardboard
(1) - bottles of dark glass (50) - cardboard boxes

Storage conditions:

List B. In a place protected from light, inaccessible to children, at a temperature of no more than 25 ° С

Shelf life:

2 years. Do not use the product with expired shelf life

Terms of leave from pharmacies:On prescription

Registration number:P N002924 / 01

Date of registration:20.04.2009

The owner of the registration certificate:SLAVYANSKAYA APTEKA, LLC SLAVYANSKAYA APTEKA, LLC Russia

Manufacturer: & nbsp

SLAVYANSKAYA APTEKA, LLC Russia

Information update date: & nbsp31.08.2015

Illustrated instructions

Instructions

Timolol (Timolol)