When applying ophthalmic gel Oftan Timogel (as well as other local ophthalmic agents), it is possible that the drug will enter the systemic bloodstream. When entering timolol into the systemic blood stream, the same undesirable phenomena can be observed, as in systemic application.
From the side of the organ of vision (local reactions): mild hyperemia
conjunctiva, sensation of foreign body in the eye, burning or pain immediately after instillation, 1-3 % transient vision loss lasting more than 3 minutes, lacrimation, photophobia, corneal epithelial edema, eyelid hyperemia, blepharitis, conjunctivitis, keratitis, ptosis, decreased corneal sensitivity, visual impairment including refractive changes (caused in some cases due to cancellation of miotics) , diplomacy; with prolonged use, it is possible to develop a surface point keratopathy. When using beta-blockers, there were cases of the development of the "dry eye" syndrome.
From the side of the cardiovascular system: bradycardia, violation of atrioventricular conduction (development of atrioventricular blockade for the first time or progression of an existing atrioventricular blockade), arterial hypotension, heart failure, arrhythmias, syncope (syncope), cerebrovascular accident, palpitation, Raynaud's syndrome, coldness of hands and feet, transient lameness , sudden cardiac arrest.
From the respiratory system: bronchospasm (in most cases in patients with obstructive bronchopulmonary diseases), respiratory failure, dyspnea and cough.
From the body as a whole: increased fatigue, asthenia, pain in the chest.
Dermatological reactions: hypersensitivity reactions, local or generalized erythema, urticaria, hair loss, psoriatic lesions of the skin or progression of psoriasis.
The incidence of these adverse events was low. In most cases, dermatological reactions disappeared after discontinuation of therapy with the drug.
From the central and peripheral nervous system: dizziness, worsening of myasthenia, paresthesia, headache, asthenia, general weakness.
Mental disorders: depression, insomnia, night fear (nightmarish dreams), memory loss.
From the digestive system: nausea, diarrhea, dyspepsia, dry mouth.
Immunologic disorders: systemic lupus erythematosus.
From the side of the urinary system: decreased libido, erectile dysfunction, Peyronie's disease.
With the systemic appointment of timolol, the following undesirablephenomena (regardless of the presence of a causal relationship with the use of the drug): aphakic cystic macular edema, dry mouth, nasal congestion, anorexia, confusion, hallucinations, increased excitability, anxiety, disorientation, drowsiness and other mental disorders, hypertension and retroperitoneal fibrosis.