The most characteristic are dizziness, nausea, headache, vomiting, constipation. Seldom there is an effect on the cardiovascular system (palpitation, tachycardia, hypotension and orthostatic collapse). Rare complications from the gastrointestinal tract (eg, abdominal pain, a feeling of fullness of the stomach) are sometimes manifested Skin reactions (prurit, rash, urticaria).
In very rare cases, motor weakness, changes in appetite, blurred vision, impaired urination develop. Very rarely there are various side effects from the mental sphere, which individually vary in intensity and manifestation (depending on the nature of the patient and the duration of therapy). This includes a change in mood (often an improvement, less often a dysphoria), a change in activity (often suppression, rarely-rising) and impaired perception (behavioral reactions, impaired sensations). Very little chance of allergic reactions (i.e.violation of respiration, bronchospasm, asthmatic component, angioedema, edema) and anaphylactic manifestations.
Very rarely develop epileptiform cramps. They are possible mainly after the administration of high doses of tramadol, or with the simultaneous administration of drugs that can lower the seizure potential (ie antidepressants or anti-psychotic drugs). Increased blood pressure and bradycardia manifest themselves in very rare cases. The possibility of worsening asthmatic conditions is not ruled out. Sometimes a respiratory depression is noted, usually in the case of a significant excess of recommended doses, or when combined with other central depressants.
It is extremely rare with long-term administration of high doses of tramadol, addiction and withdrawal reactions may develop: agitation, agitation, nervousness, insomnia, hyperkinesia, tremor and gastrointestinal disturbances. In a number of cases there is an increase in liver enzyme levels when taking tramadol.