The most frequent adverse reactions are nausea and dizziness, noted in more than 10% of patients.
The frequency is defined as follows:
Very often:> 1/10;
Frequently:> 1/100 <1/10;
Infrequently:> 1/1000 <1/100;
Rarely:> 1/10 000 <1/1000;
Very rarely: <1/10 000;
Insufficient data: can not be determined on the basis of available data.
Disorders from the cardiovascular system:
Infrequent: effects on cardiovascular regulation (palpitations, tachycardia, orthostatic hypotension or collapse). These side effects are mainly observed with intravenous administration of the drug or with significant physical exertion.
Rarely: bradycardia, increased blood pressure.
Disorders from the metabolism and nutrition:
Rarely: changes in appetite.
Disturbances from the respiratory system:
Rarely: respiratory depression, shortness of breath.
At a significant excess of the recommended doses with simultaneous use of other drugs that depress the central nervous system (CNS), respiratory depression is possible.
There was a deterioration in bronchial asthma, however, there was no causal relationship with the drug.
Impaired nervous system:
Very often: dizziness.
Often: headache, drowsiness.
Rarely: speech disorders, paresthesia, tremor, epileptiform seizures, involuntary muscle contractions, coordination disorders, fainting. Epileptiform seizures are possible after applying high doses of tramadol and with simultaneous use with drugs that lower the threshold of convulsive readiness.
Disorders of the psyche:
Rarely: hallucinations, confusion, sleep disturbances, anxiety, delirium and nightmares. After the use of tramadol, various rarely observed undesirable reactions from the psyche are possible (depending on the personality characteristics of the patient and the duration of treatment). These side effects include mood changes (usually euphoria, sometimes dysphoria), a change in activity (usually a decrease,sometimes an increase), a violation of cognitive functions and perception (eg, decision-making, perception disorders). Perhaps the development of drug dependence.
Disorders from the side of the organ of vision:
Rarely: miosis, mydriasis, blurred vision.
Disorders from the gastrointestinal tract:
Very often: nausea.
Often: constipation, dry mouth, vomiting.
Infrequent: vomiting, a feeling of heaviness in the epigastrium, flatulence, diarrhea.
Disturbances from the skin and subcutaneous tissues:
Often: sweating.
Infrequent: itching, rash, hives.
Disturbances from the musculoskeletal and connective tissue:
Rarely: muscle weakness.
Disorders from the liver and bile ducts:
In some cases there was an increase in the activity of "hepatic" enzymes, which coincided in time with tramadol therapy.
From the side of the kidneys and the urinary system:
Rarely: disturbances of urination (difficulty with urination, dysuria and urinary retention).
Immune system disorders:
Rarely: allergic reactions (dyspnea, bronchospasm, wheezing, angioedema) and anaphylaxis.
General disorders:
Often: fatigue.
Rarely: the possible symptoms of "withdrawal" are similar to the symptoms of "withdrawal" of opioids: agitation, anxiety, nervousness, sleep disturbance, hyperkinesia, tremor and gastrointestinal symptoms.
Other symptoms that are very rare with tramadol cancellation include panic attacks, severe anxiety, hallucinations, paresthesia, ringing in the ears and other extremely rare CNS symptoms (confusion, hallucinations, depersonalization, derealization, paranoia).
If any of these side effects occur, or if there are other side effects not indicated in the instructions, tell your doctor.