The most common side effects are nausea and dizziness,
noted in more than 10% of patients.
The frequency is defined as follows:
Often: >1/10;
Often: >1/100, <1/10;
Infrequently: >1/1000, <1/100;
Rarely: >1/10 000, <1/1000;
Very rarely: <1/10 000;
The frequency is unknown: it can not be determined from the available data.
From the side of the cardiovascular system
Infrequently: the effect on cardiovascular regulation (palpitation,
tachycardia, orthostatic hypotension or collapse). These side effects in
mainly observed with intravenous administration of the drug or with
significant physical exertion.
Rarely: bradycardia, increased blood pressure.
From the side of metabolism and nutrition
Rarely: changes in appetite.
From the respiratory system
Rarely: respiratory depression, shortness of breath.
At a significant excess of the recommended doses with simultaneous use of other drugs that depress the central nervous system (CNS), respiratory depression is possible.
There was a deterioration in bronchial asthma, however, the cause-
the investigational link with the use of the drug is not established.
From the nervous system
Very often: dizziness.
Often: headache, drowsiness.
Rarely: paresthesia, tremors, convulsions, involuntary muscle contractions, coordination disorders, fainting.
Seizures are possible after applying high doses of tramadol and with simultaneous use with drugs that reduce the threshold of convulsive readiness.
Frequency is unknown: speech disorders.
From the side of the psyche
Rarely: hallucinations, confusion, sleep disorders, anxiety and nightmares. After the use of tramadol, various rarely observed undesirable reactions from the psyche are possible (depending on the personality characteristics of the patient and the duration of treatment). These undesirable drug reactions include mood changes (usually euphoria, sometimes dysphoria), changes in motor activity (usually a decrease, sometimes an increase), impairment of cognitive functions and perception (eg, decision making, perceptual disorders). Perhaps the development of drug dependence. Possible symptoms of "cancellation" are similar to the symptoms of opioid withdrawal: agitation, anxiety, nervousness, sleep disorders, hyperkinesia, tremor and gastrointestinal symptoms.
Other symptoms that are very rare with tramadol cancellation include panic attacks, severe anxiety, hallucinations, paresthesia,tinnitus and other very rare symptoms of the central nervous system (disorientation in time and space, hallucinations, depersonalization, derealization, paranoia).
From the side of the organ of vision
Rarely: blurred vision. The frequency is unknown: mydriasis.
From the side of the digestive system
Very often: nausea.
Often: constipation, dry mouth, vomiting.
Infrequent: vomiting, a feeling of heaviness in the epigastrium, flatulence, diarrhea.
From the skin and subcutaneous tissue
Often: sweating.
Infrequent: itching, rash, hives.
From the musculoskeletal system
Rarely: muscle weakness.
From the liver and biliary tract
In some cases, there is increased activity of "liver" enzymes coincides in time with tramadol therapy.
From the kidneys and urinary system
Rarely: disturbances of urination (difficulty with urination, dysuria and urinary retention).
From the immune system
Rarely: allergic reactions (dyspnoea, bronchoconstriction, wheezing,
angioedema) and anaphylaxis.
General disorders
Often: increased fatigue.