The most common side effects are nausea and dizziness, noted in more than 10% of patients.
The frequency is defined as follows:
Often: >1/10;
Often: >1/100, <1/10;
Infrequently: >1/1000, <1/100;
Rarely: >1/10 000, <1/1000;
Very rarely: <1/10 000;
Insufficient data: can not be determined based on available data.
From the cardiovascular system:
Infrequent: effects on cardiovascular regulation (palpitations, tachycardia, orthostatic hypotension or collapse). These side effects are mainly observed with intravenous administration of the drug or with significant physical exertion.
Rarely: bradycardia, increased blood pressure.
Disorders from the metabolism and nutrition:
Rarely: changes in appetite.
From the respiratory system: Rarely: respiratory depression, shortness of breath.
At a significant excess of the recommended doses with simultaneous use of other drugs that depress the central nervous system (CNS), respiratory depression is possible.
There was a deterioration in bronchial asthma, but the cause-
the investigational link with the use of the drug was not established.
Impaired nervous system:
Very often: dizziness.
Often: headache, drowsiness.
Rarely: speech disorders, paresthesia, tremor, epileptiform seizures, involuntary muscle contractions, coordination disorders, fainting.
Epileptiform seizures are possible after applying high doses of tramadol and with simultaneous use with drugs that lower the threshold of convulsive readiness.
Disorders of the psyche:
Rarely: hallucinations, confusion, sleep disturbances, anxiety, delirium and nightmares. After the use of tramadol, various rarely observed undesirable reactions from the psyche are possible (depending on the personality characteristics of the patient and the duration of treatment).These side effects include mood changes (usually euphoria, sometimes dysphoria), changes in activity (usually a decrease, sometimes an increase), impairment of cognitive functions and perception (eg, decision-making, perceptual disorders). Perhaps the development of drug dependence.
From the side of the organ of vision:
Rarely: miosis, mydriasis, blurred vision.
On the part of the digestive system:
Very often: nausea.
Often: constipation, dry mouth, vomiting.
Infrequent: vomiting, a feeling of heaviness in the epigastrium, flatulence, diarrhea.
From the skin and subcutaneous tissue:
Often: sweating.
Infrequent: itching, rash, hives.
From the musculoskeletal system:
Rarely: muscle weakness.
From the liver and bile ducts:
In a few isolated cases, an increase in the activity of liver enzymes
time coinciding with therapy with tramadol.
From the side of the kidneys and the urinary system:
Rarely: disturbances of urination (dysuria and urinary retention).
Immune system disorders:
Rarely: allergic reactions (dyspnea, bronchospasm, wheezing, angioedema) and anaphylaxis.
General disorders:
Often: fatigue.
Rarely: the possible symptoms of "cancellation" are similar to the symptoms of "withdrawal" of opioids: agitation, anxiety, nervousness, sleep disorders, hyperkinesia, tremor and gastrointestinal symptoms. Other symptoms that are very rare with tramadol cancellation include panic attacks, severe anxiety, hallucinations, paresthesia, ringing in the ears and other extremely rare CNS symptoms (confusion, hallucinations, depersonalization, derealization, paranoia).
If any of the following side effects occur, or if there are other side effects not indicated in the instructions, tell your doctor.