Trigidron - instructions for use, dose, side effects, contraindications

Active substanceDextrose + Potassium chloride + Sodium chloride + Sodium citrateDextrose + Potassium chloride + Sodium chloride + Sodium citrate

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Trigidron®

powder inwards

MARBIOFARM, OJSC Russia

Dosage form: & nbspPowder for solution for oral administration

Composition:

Composition per package: potassium chloride 1.25 g, sodium chloride 1.75 g, dextrose monohydrate (glucose monohydrate) 5.00 g (in terms of dextrose), sodium citrate pentaeksviquidrate 1.27 g (in terms of sodium citrate).

The solution obtained by dissolving Trigorin® contains the following concentrations of active ingredients:

Potassium chloride	33.5 mmol / l
Sodium chloride	59.8 mmol / l
Sodium citrate penta-x-ray hydrate	9.8 mmol / l
Dextrose	55.5 mmol / l
Na⁺	89.5 mmol / l
TO⁺	34 mmol / l
cg	94 mmol / l
Citrate	9.8 mmol / l

Description:Description: granular white powder odorless. It is allowed to have crystals and easily crumbling lumps.

Pharmacotherapeutic group:rehydrating agent for oral administration.

ATX: & nbsp

A.07.C.A Rehydrate for oral use

Pharmacodynamics:

Rehydrating agent.Prevents or reduces dehydration by restoring sodium and potassium salts, restores water-electrolyte balance in diarrhea. Dextrose promotes the absorption of electrolytes, which contributes to the correction of metabolic acidosis.

Pharmacokinetics:

The drug is retained in the vascular bed for a short time and very quickly passes into the interstitial sector and into the cells. Already after 1 hour in the bloodstream remains half of the solution withdrawn. Very quickly excreted by the kidneys, increasing diuresis. With renal failure, excretion of the potassium in the preparation can be slowed down.

Indications:

Oral rehydration and prevention of dehydration during mild to moderate dehydration due to acute diarrhea, in order to replenish water and electrolyte losses.

Contraindications:

Unconscious state. Intestinal obstruction. Hypersensitivity to the components of the drug, impaired renal function; diarrhea due to cholera; severe dehydration, hemodynamic shock, severe vomiting.

Carefully:

Diabetes.

Pregnancy and lactation:

In recommended doses, the drug can be used in pregnancy and lactation.

Dosing and Administration:

Inside. Before use, the contents of the packet are dissolved in 0.5 l of freshly boiled water at room temperature. The prepared solution should be stored in a cool place in the refrigerator (at a temperature of +2 - +8 ° C) and used within 24 hours. Do not add any other ingredients to the solution in order not to interfere with the effect of the drug.

Before starting treatment, the patient should be weighed to assess the loss of body weight and the degree of dehydration.

It is recommended to avoid eating foods rich in fats and simple carbohydrates during treatment with the drug. To prevent dehydration, Trihydron® should be started as soon as diarrhea has started. Usually the drug should be taken no more than 3-4 days, the treatment ends with the end of diarrhea.

If the patient experiences nausea or vomiting, it is advisable to give the solution in chilled form in small portions.

Rehydration. For rehydration, Trigidron® is taken within the first 6 to 10 hours in an amount that is twice the body weight loss caused by diarrhea.For example, if the body weight loss is 400 g, the volume of the Trihydron® solution is 800 ml. During this phase, the use of other liquids is not required.

Follow-up therapy. If diarrhea continues, after correction of dehydration, it is advisable to administer Trigydron® or water for 24 hours as follows:

Body weight (kg)	Total amount of liquid required (l)	Trigidron® (ml)	Water (ml)	Other fluids (ml)
40-49	2,10	900	540	660
50-59	2,30	1000	600	700
60-69	2,50	1100	660	740
70-79	2,70	1200	720	780
80-89	3,20	1400	800	1000
90-99	3,60	1500	900	1200
100 and more	4,00	1700	1000	1300

Side effects:

The risk of hypernatremia and hyperhydration in patients with normal renal function is low. With rapid administration of the drug may cause vomiting.

Overdose:

When introducing a large volume or a highly concentrated solution of Trigorin® (if the rules for preparing the solution are violated), hypernatremia may occur.

Symptoms of hypernatremia: weakness, neuromuscular excitement, drowsiness, confusion, coma, sometimes even stopping breathing. Patients with reduced renal function may experience metabolic alkalosis, which may be manifested by pulmonary ventilation depression, neuromuscular arousal, and tetanic seizures.

If Trigidron® is used in patients with impaired excretion of potassium salts from the body, hyperkalaemia (increased potassium content in the blood) may develop, which can manifest itself as sensory and paralyzed limb, skin itching, confusion, falling blood pressure, palpitations, and even in stopping the heart, which can come suddenly, amid well-being.

In case of symptoms of overdose, see a doctor. Correction of water-electrolyte balance should be carried out on the basis of laboratory data.

Interaction:

Not studied. The solution of the preparation has a slightly alkaline reaction, therefore it can influence the drugs, the absorption of which depends on the pH of the contents of the intestine. Diarrhea itself can alter the absorption of many drugs that are absorbed in the small or large intestine, or drugs in the metabolism of which there is intestinal hepatic recirculation.

Special instructions:

Children should use other solutions with a lower sodium concentration and osmolarity. Severe dehydration (weight loss> 10%, anuria) should be stopped with the use of intravenous preparations for rehydration, after which Trigidron® can be used.

The recommended dose of the drug should not be exceeded if the patient's need for additional electrolyte administration is not confirmed by laboratory tests.

Do not add sugar to the solution. Food can be given immediately after rehydration. When vomiting should wait for 10 minutes after the completion of attacks of vomiting and give a drink of the solution slowly, in small sips.

Patients in whom dehydration developed against renal failure, diabetes mellitus, or other chronic diseases, accompanied by a violation of acid-base, electrolyte balance or carbohydrate metabolism, require careful monitoring during therapy with Trigidron®.

The patient should consult a doctor if the following situations occur during the use of Trigidron®:

- there is slow speech, rapid fatigue, drowsiness, stupor;

- body temperature rises above 39 ° C;

- discontinuation of urine;

- there is a liquid bloody stool;

- Diarrhea lasts more than 2 days;

- diarrhea suddenly stops, severe pains appear in the abdomen;

- if treatment at home is unsuccessful or impossible.

Effect on the ability to drive transp. cf. and fur:Trigidron® does not affect the ability to drive vehicles and engage in other potentially hazardous activities requiring increased concentration and speed of psychomotor reactions.

Form release / dosage:

Powder for solution for oral administration.

For 9.45 grams in heat-sealed bags of packaging combined material.

For 10 or 20 bags, together with the instruction for use, they are placed in packs of cardboard for consumer containers.

Packaging:packages from the combined material heat-sealing (10) -tacks, cardboard
packages made of the combined material, heat-sealing (20) -tacks, cardboard

Storage conditions:

In a dry, protected from light place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-001981

Date of registration:23.01.2013

The owner of the registration certificate:MARBIOFARM, OJSC MARBIOFARM, OJSC Russia

Manufacturer: & nbsp

MARBIOFARM, OJSC Russia

Information update date: & nbsp15.07.2013

Illustrated instructions

Instructions

Trigidron® (Trigidron®)